Comby S, Carret G, Pave A, Flandrois J P, Pichat C
Laboratoire de Bactériologie, Université Claude-Bernard, CNRS URA 243, Hôtel Dieu, Lyon.
Pathol Biol (Paris). 1989 May;37(5):335-40.
The growth of Escherichia coli in synthetic medium was mathematically analysed at subinhibitory levels of bactericidal and bacteriostatic antibiotics. Over a threshold of concentration, bactericidal antibiotics induce an unexpected change of growth pattern. Bacteriostatic antibiotics induce a progressive effect linked to a continuously altered growth pattern that still remains close to the controls. This fundamental differential of antibiotic effects is reflecting well-known bacteriostatic or bactericidal phenomena. In vitro this analysis of the growth enables to measure the level of the antibiotic sensitivity. In vivo, these results must be taken into account when subinhibitory concentrations of antimicrobial agent are reached at the infection site.
在合成培养基中，对处于杀菌和抑菌抗生素亚抑制水平的大肠杆菌生长情况进行了数学分析。超过浓度阈值时，杀菌抗生素会引发意想不到的生长模式变化。抑菌抗生素会引发一种与持续改变的生长模式相关的渐进效应，这种生长模式仍与对照相近。抗生素效应的这种基本差异反映了众所周知的抑菌或杀菌现象。在体外，这种对生长情况的分析能够测量抗生素敏感性水平。在体内，当感染部位达到抗菌剂的亚抑制浓度时，必须考虑这些结果。
