Carret G, Charpe B, Cheruy A, Flandrois J P, Pave A, Couix C
Pathol Biol (Paris). 1987 May;35(5):483-93.
The effect of subinhibitory concentrations of 5 antibiotics on the growth rate of 2 bacteria (Staphylococcus aureus and Escherichia coli) has been studied. Chloramphenicol, dibekacin, netilmicin and nalidixic acid have a direct effect on the growth rate. Apparently, aminoglycosides and nalidixic acid have an accompanying effect on the affinity for the energizing substrate. Amoxicillin does not seem to be concerned by this 2 mechanisms. The interest of the estimation of the growth rate by an adaptative algorithm has been pointed out.
研究了5种抗生素亚抑菌浓度对两种细菌(金黄色葡萄球菌和大肠杆菌)生长速率的影响。氯霉素、双去氧卡那霉素、奈替米星和萘啶酸对生长速率有直接影响。显然,氨基糖苷类抗生素和萘啶酸对与供能底物的亲和力有附带影响。阿莫西林似乎不受这两种机制的影响。文中指出了通过自适应算法估算生长速率的意义。