人类干细胞可在植入后的小鼠胚胎中分化。

Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos.

机构信息

Embryology Unit, Children's Medical Research Institute, Sydney Medical School, University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia.

出版信息

Cell Stem Cell. 2016 Jan 7;18(1):3-4. doi: 10.1016/j.stem.2015.12.010.

DOI:10.1016/j.stem.2015.12.010

PMID:26748747

Abstract

The potency of human pluripotent stem cells (hPSCs) to differentiate into germ layer derivatives is conventionally assessed by teratoma induction and in vitro differentiation. In this issue of Cell Stem Cell, Mascetti and Pedersen (2016) demonstrate that the human-mouse post-implantation chimera offers an efficient avenue to test the germ layer differentiation potential of hPSCs in mouse embryos ex vivo.

摘要

人类多能干细胞（hPSCs）分化为胚层衍生物的效力通常通过畸胎瘤诱导和体外分化来评估。在本期《细胞-干细胞》杂志中，Mascetti 和 Pedersen（2016）证明了人-鼠胚胎嵌合体为在体外测试 hPSCs 在小鼠胚胎中的胚层分化潜力提供了一种有效的途径。