Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell Stem Cell. 2016 Jan 7;18(1):13-5. doi: 10.1016/j.stem.2015.12.004.
Harsh environments within damaged and diseased tissues and limited retention and survival of injected stem cells pose major challenges for stem cell therapeutics today. Here, we discuss promising hydrogel-based strategies for improving engraftment and viability of transplanted stem cells and stimulating recruitment of endogenous stem cells for repair.
在受损和患病组织内恶劣的环境以及注入的干细胞有限的保留和存活，是当今干细胞治疗所面临的主要挑战。在这里，我们讨论了有前景的基于水凝胶的策略，这些策略可改善移植干细胞的植入和活力，并刺激内源性干细胞的募集以进行修复。
