重症犬血栓弹力图结果与死后血栓形成证据的回顾性比较：39例（2005 - 2010年）
Retrospective comparison of thromboelastography results to postmortem evidence of thrombosis in critically ill dogs: 39 cases (2005-2010).
作者信息
Thawley Vincent J, Sánchez Melissa D, Drobatz Kenneth J, King Lesley G
机构信息
Section of Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
Department of Clinical Studies - Philadelphia, and the Laboratory of Pathology and Toxicology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
出版信息
J Vet Emerg Crit Care (San Antonio). 2016 May;26(3):428-36. doi: 10.1111/vec.12441. Epub 2016 Jan 8.
OBJECTIVE
To determine whether there is an association between thromboelastography (TEG) data and necropsy evidence of thrombosis in a cohort of critically ill dogs.
DESIGN
Retrospective study (2005-2010).
SETTING
University teaching hospital.
ANIMALS
Thirty-nine client-owned critically ill dogs for which TEG was performed within 7 days of complete necropsy.
INTERVENTIONS
None.
MEASUREMENTS AND MAIN RESULTS
Thrombi were found in 26 (67%) dogs. Spayed females (n = 20) were significantly more likely to have thrombosis (P = 0.0127). No significant association was found between presence of thrombosis and any TEG parameter, the calculated coagulation index, results of coagulation testing, type of vascular access, or clinical diagnosis. D-dimers were significantly higher in dogs with thrombosis (P = 0.0207) and a weak positive correlation was found between D-dimer value and number of sites of thrombosis (ρ = 0.18, P = 0.0045). Dogs with WBC > 16 × 10(3) /μL were more likely to have thrombosis compared to others (odds ratio 5.56, 95% confidence interval 1.2-25.7, P = 0.025).
CONCLUSIONS
This study found no association between any TEG parameter and the presence of thrombosis on postmortem examination.
目的
确定在一组重症犬中，血栓弹力图（TEG）数据与血栓形成的尸检证据之间是否存在关联。
设计
回顾性研究（2005 - 2010年）。
地点
大学教学医院。
动物
39只客户拥有的重症犬，在完整尸检的7天内进行了TEG检测。
干预措施
无。
测量指标及主要结果
26只（67%）犬发现血栓。绝育雌性犬（n = 20）发生血栓的可能性显著更高（P = 0.0127）。在血栓形成与任何TEG参数、计算的凝血指数、凝血检测结果、血管通路类型或临床诊断之间未发现显著关联。血栓形成的犬D - 二聚体显著更高（P = 0.0207），且D - 二聚体值与血栓形成部位数量之间存在弱正相关（ρ = 0.18，P = 0.0045）。白细胞>16×10³/μL的犬比其他犬更易发生血栓（优势比5.56，95%置信区间1.2 - 25.7，P = 0.025）。
结论
本研究发现尸检时任何TEG参数与血栓形成之间均无关联。
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