Kamalov Meder, Kaur Harveen, Brimble Margaret A
Institute of Biological Chemistry, Faculty of Chemistry, Währinger Straße 38, 1090, Vienna, Austria.
School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland, 1142, New Zealand.
Chemistry. 2016 Mar 7;22(11):3622-31. doi: 10.1002/chem.201503458. Epub 2016 Jan 8.
Synthetic methods aimed at preparing peptides cross-linked by diaminodiacids remain an important chemical challenge. These cross-links are known to play a crucial role on the activity, structural stability, and folding of the host peptides and proteins. Recent developments in the syntheses of such systems have led to intriguing advances in the understanding of intermolecular side-chain cross-linking and the role that these structural motifs play in the biochemistry of proteins. Herein we provide an overview of the existing synthetic methodology that has been developed to effect protein cross-linking using diaminodiacids.
旨在制备由二氨基二酸交联的肽的合成方法仍然是一项重要的化学挑战。已知这些交联在主体肽和蛋白质的活性、结构稳定性及折叠中起着关键作用。此类体系合成方面的最新进展在理解分子间侧链交联以及这些结构基序在蛋白质生物化学中所起的作用方面带来了引人入胜的进展。在此，我们概述了已开发出的使用二氨基二酸实现蛋白质交联的现有合成方法。
