Götz Tobias, Schädel Nicole, Petri Nadja, Kirchhof Manuel, Bilitewski Ursula, Tovar Günter E M, Laschat Sabine, Southan Alexander
Institute of Interfacial Process Engineering and Plasma Technology IGVP, University of Stuttgart Nobelstraße 12 70569 Stuttgart Germany
Institute of Organic Chemistry IOC, University of Stuttgart Pfaffenwaldring 55 70569 Stuttgart Germany
RSC Adv. 2018 Oct 10;8(60):34743-34753. doi: 10.1039/c8ra07145d. eCollection 2018 Oct 4.
Triazole-based cross-linkers with different spacer lengths and different functional end groups (acrylamides, methacrylamides, maleimides and vinylsulfonamides) were synthesized, investigated for cytotoxic and antibacterial activity, and incorporated into poly(acrylamide) (PAAm) and poly(,-dimethylacrylamide) (PDMAAm) hydrogels by free-radical polymerization. Hydrogels prepared with different cross-linkers and cross-linker contents between 0.2% and 1.0% were compared by gel yields, equilibrium degrees of swelling () and storage moduli ('). Generally with increasing cross-linker content, ' values of the hydrogels increased, while values decreased. The different polymerizable cross-linker end groups resulted in a decrease of ' in the following order for cross-linkers with C spacers: acrylamide > maleimide > methacrylamide > vinylsulfonamide. Longer cross-linker alkyl spacer lengths caused an increase in ' and a decrease in . Independent of the cross-linker used, a universal correlation between ' and equilibrium polymer volume fraction was found. For PAAm hydrogels, ' ranged between 4 kPa and 23 kPa and between 0.07 and 0.14. For PDMAAm hydrogels, ' ranged between 0.1 kPa and 4.9 kPa and between 0.02 and 0.06. The collected data were used to establish an empirical model to predict ' depending on . ' of PAAm and PDMAAm hydrogels is given by ' = 4034 kPa and ' = 4297 kPa , respectively.
合成了具有不同间隔长度和不同功能端基（丙烯酰胺、甲基丙烯酰胺、马来酰亚胺和乙烯基磺酰胺）的基于三唑的交联剂，研究了其细胞毒性和抗菌活性，并通过自由基聚合将其引入到聚丙烯酰胺（PAAm）和聚（N，N-二甲基丙烯酰胺）（PDMAAm）水凝胶中。通过凝胶产率、平衡溶胀度（）和储能模量（'）对用不同交联剂和交联剂含量在0.2%至1.0%之间制备的水凝胶进行了比较。一般来说，随着交联剂含量的增加，水凝胶的'值增加，而值降低。对于具有C间隔的交联剂，不同的可聚合交联剂端基导致'按以下顺序降低：丙烯酰胺>马来酰亚胺>甲基丙烯酰胺>乙烯基磺酰胺。较长的交联剂烷基间隔长度导致'增加而降低。与所使用的交联剂无关，发现'与平衡聚合物体积分数之间存在普遍相关性。对于PAAm水凝胶，'在4 kPa至23 kPa之间，在0.07至0.14之间。对于PDMAAm水凝胶，'在0.1 kPa至4.9 kPa之间，在0.02至0.06之间。收集的数据用于建立一个经验模型来预测取决于的'。PAAm和PDMAAm水凝胶的'分别由' = 4034 kPa 和' = 4297 kPa 给出。
