金催化手性高炔丙基磺酰胺的串联环异构化-卤化反应
Gold-Catalyzed Tandem Cycloisomerization-Halogenation of Chiral Homopropargyl Sulfonamides.
作者信息
Shu Chao, Li Long, Shen Cang-Hai, Ruan Peng-Peng, Liu Chao-Yue, Ye Long-Wu
机构信息
State Key Laboratory of Physical Chemistry of Solid Surfaces and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, Fujian, P. R. China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
出版信息
Chemistry. 2016 Feb 12;22(7):2282-90. doi: 10.1002/chem.201503891. Epub 2016 Jan 8.
Two new gold-catalyzed tandem cycloisomerization-halogenation reactions of chiral homopropargyl sulfonamides have been developed. Various enantioenriched 3,3-diiodopyrrolidin-2-ols and 3-fluoropyrrolidin-2-ols were obtained in moderate-to-good yields with excellent enantio- and diastereoselectivity.
已开发出手性高炔丙基磺酰胺的两种新型金催化串联环异构化-卤化反应。以中等至良好的产率获得了各种对映体富集的3,3-二碘吡咯烷-2-醇和3-氟吡咯烷-2-醇，对映选择性和非对映选择性均优异。
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