Stereoselective synthesis of 2,5-disubstituted pyrrolidines via gold-catalysed anti-Markovnikov hydroamination-initiated tandem reactions.

作者信息

Tan Tong-De, Chen Yang-Bo, Yang Ming-Yang, Wang Jia-Le, Su Hao-Ze, Hong Feng-Lin, Zhou Jin-Mei, Ye Long-Wu

机构信息

State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

出版信息

Chem Commun (Camb). 2019 Aug 15;55(67):9923-9926. doi: 10.1039/c9cc05295j.

A series of gold-catalysed intramolecular anti-Markovnikov hydroamination-initiated azidation, allylation and heteroarylation reactions of chiral homopropargyl sulfonamides have been developed. Various enantioenriched 2,5-disubstituted pyrrolidines are obtained in moderate to excellent yields with excellent enantioselectivities and generally high diastereoselectivities.