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Human plasma alpha 1-acid glycoprotein--biochemical properties, the amino acid sequence and the structure of the carbohydrate moiety, variants and polymorphism.

作者信息

Schmid K

机构信息

Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, MA 02118.

出版信息

Prog Clin Biol Res. 1989;300:7-22.

PMID:2674975
Abstract
摘要

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Human plasma alpha 1-acid glycoprotein--biochemical properties, the amino acid sequence and the structure of the carbohydrate moiety, variants and polymorphism.人血浆α1-酸性糖蛋白——生化特性、氨基酸序列、糖部分结构、变体与多态性
Prog Clin Biol Res. 1989;300:7-22.
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Bioorg Khim. 1994 Dec;20(12):1297-309.
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Contribution of the variants of alpha 1-acid glycoprotein to its binding of drugs.α1-酸性糖蛋白变体对其与药物结合的贡献。
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Structures of the oligosaccharide chains of two forms of alpha 1-acid glycoprotein purified from liver metastases of lung, colon, and breast tumors.从肺、结肠和乳腺肿瘤肝转移灶中纯化的两种形式的α1-酸性糖蛋白的寡糖链结构
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Glycan moiety modifications of feline alpha1-acid glycoprotein in retrovirus (FIV, FeLV) affected cats.逆转录病毒（猫免疫缺陷病毒、猫白血病病毒）感染猫中猫α1-酸性糖蛋白的聚糖部分修饰
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Glycan microheterogeneity forms of alpha 1-acid glycoprotein (AGP): their identification in biological fluids and variations in their relative proportions in disease states.α1-酸性糖蛋白（AGP）的聚糖微异质性形式：它们在生物体液中的鉴定及其在疾病状态下相对比例的变化。
Prog Clin Biol Res. 1989;300:47-65.
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Drug binding sites on human alpha-1-acid glycoprotein.人α-1-酸性糖蛋白上的药物结合位点。
Prog Clin Biol Res. 1989;300:363-78.
8
Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2.在中国仓鼠卵巢细胞中表达的重组人组织因子途径抑制剂的氨基酸序列和碳水化合物结构：一条N-连接和两条O-连接的碳水化合物链位于Kunitz结构域2和3之间，一条N-连接的碳水化合物链位于Kunitz结构域2中。
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The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin.通过紫外光交联免疫沉淀法解析得到的α1-酸性糖蛋白（类粘蛋白）1.8埃晶体结构，揭示了这种人血浆脂质运载蛋白广泛的药物结合活性。
J Mol Biol. 2008 Dec 12;384(2):393-405. doi: 10.1016/j.jmb.2008.09.020. Epub 2008 Sep 16.
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Isoelectric focusing of alpha-1 acid glycoprotein (orosomucoid) in immobilized pH-gradients with 8M urea: detection of its desialylated variants using an alkaline phosphatase-linked secondary antibody system.在含8M尿素的固定化pH梯度中对α-1酸性糖蛋白（类粘蛋白）进行等电聚焦：使用碱性磷酸酶连接的二抗系统检测其去唾液酸化变体。
Electrophoresis. 1988 Oct;9(10):650-4. doi: 10.1002/elps.1150091005.

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Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein.
药物与α-1-酸性糖蛋白结合的药代动力学和药效学考虑因素。
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Sialic acid residues play a pivotal role in alpha(1)-acid glycoprotein (AGP)-induced generation of reactive oxygen species in chemotactic peptide pre-activated neutrophil granulocytes.唾液酸残基在趋化肽预激活的中性粒细胞中α(1)-酸性糖蛋白（AGP）诱导活性氧生成中起关键作用。
Inflamm Res. 2010 Feb;59(2):89-95. doi: 10.1007/s00011-009-0071-1. Epub 2009 Aug 11.
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Orosomucoid in urine is a powerful predictor of cardiovascular mortality in normoalbuminuric patients with type 2 diabetes at five years of follow-up.在对正常白蛋白尿的2型糖尿病患者进行五年随访时，尿中血清类黏蛋白是心血管疾病死亡率的有力预测指标。
Diabetologia. 2005 Feb;48(2):386-93. doi: 10.1007/s00125-004-1630-1. Epub 2005 Jan 11.
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Role of biantennary glycans and genetic variants of human alpha1-acid glycoprotein in enantioselective binding of basic drugs as studied by high performance frontal analysis/capillary electrophoresis.通过高效前沿分析/毛细管电泳研究双天线聚糖和人α1-酸性糖蛋白基因变体在碱性药物对映体选择性结合中的作用。
Pharm Res. 2001 Mar;18(3):389-93. doi: 10.1023/a:1011023518144.
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Alpha-1-acid (AAG, orosomucoid) glycoprotein: interaction with bacterial lipopolysaccharide and protection from sepsis.α-1-酸性（AAG，类粘蛋白）糖蛋白：与细菌脂多糖的相互作用及对败血症的保护作用。
Inflammation. 1997 Feb;21(1):69-82. doi: 10.1023/a:1027342909423.