Barton Cynthia, Ketelle Robin, Merrilees Jennifer, Miller Bruce
Department of Neurology, Memory and Aging Center, University of California, 675 Nelson Rising Lane, Suite 190, Box 1207, San Francisco, CA, 94158, USA.
School of Nursing, University of California, 2 Koret Way, Box 1207, San Francisco, CA, 94143, USA.
Curr Neurol Neurosci Rep. 2016 Feb;16(2):14. doi: 10.1007/s11910-015-0618-1.
Worldwide prevalence of dementia is predicted to double every 20 years. The most common cause in individuals over 65 is Alzheimer's disease (AD), but in those under 65, frontotemporal dementia (FTD) is as frequent. The physical and cognitive decline that characterizes these diseases is commonly accompanied by troublesome behavioral symptoms. These behavioral symptoms contribute to significant morbidity and mortality among both patients and caregivers. Medications have been largely ineffective in managing these symptoms and carry significant adverse effects. Non-pharmacological interventions have been recommended to precede the utilization of pharmacological treatments. This article reviews the research about these interventions with special attention to the variations by etiology, especially FTD. The authors offer recommendations for improving utilization of these strategies and future research recommendations.
据预测,全球痴呆症患病率每20年将翻一番。65岁以上人群中最常见的病因是阿尔茨海默病(AD),但在65岁以下人群中,额颞叶痴呆(FTD)的发病率同样很高。这些疾病的身体和认知衰退通常伴随着令人困扰的行为症状。这些行为症状导致患者和护理人员出现显著的发病率和死亡率。药物在控制这些症状方面大多无效,且具有显著的不良反应。建议在使用药物治疗之前先进行非药物干预。本文回顾了有关这些干预措施的研究,并特别关注病因的差异,尤其是FTD。作者提出了提高这些策略利用率的建议以及未来的研究建议。