Detke M J, Brandon S E, Weingarten H P, Rodin J, Wagner A R
Department of Psychology, Yale University, New Haven, CT 06520.
Physiol Behav. 1989 Apr;45(4):845-51. doi: 10.1016/0031-9384(89)90305-3.
A context-like conditioned stimulus (CS) previously paired with a food unconditioned stimulus (US) enhanced both food-related activity and insulin secretion in rats. Experiment 1 documented the effectiveness of an appetitive conditioning procedure in which a 10 sec visual CS ("x") was followed by food when embedded within one 35 sec auditory CS ("A"), but not another ("B"). Approach to a food magazine during x was enhanced (facilitated) when x was within A, as compared to within B or alone. Experiment 2 documented the adequacy of blood sampling and insulin assay procedures that could be accommodated to the conditioning procedure. Plasma insulin was observably different after unconditioned deliveries of glucose solutions of different intensities. In Experiment 3, training as in Experiment 1 was followed by testing for food magazine approach and changes in insulin levels following x alone or in the presence of A or B. It was demonstrated that the A cue enhanced both responses. The results support the view [e.g., (18,19)] that insulin secretion is in part under the control of environmental cues, and findings (22) that show that conditioned context-like cues can modulate consummatory responding to punctate CSs.
先前与食物非条件刺激（US）配对的类似情境的条件刺激（CS）增强了大鼠与食物相关的活动和胰岛素分泌。实验1记录了一种食欲性条件作用程序的有效性，即在一个35秒的听觉CS（“A”）中嵌入一个10秒的视觉CS（“x”）后给予食物，但在另一个（“B”）中则不然。与在B中或单独出现时相比，当x在A中时，大鼠在x期间接近食物盒的行为增强（促进）。实验2记录了血液采样和胰岛素测定程序的适用性，这些程序可以适应条件作用程序。在给予不同强度的葡萄糖溶液非条件刺激后，血浆胰岛素有明显差异。在实验3中，按照实验1进行训练，然后测试单独出现x或在A或B存在时大鼠接近食物盒的行为以及胰岛素水平的变化。结果表明，A线索增强了两种反应。这些结果支持了胰岛素分泌部分受环境线索控制的观点[例如，（18,19）]，以及表明类似情境的条件线索可以调节对点状CS的 consummatory反应的研究结果（22）。
