Howard C F, Kessler M J, Schwartz S
Oregon Regional Primate Research Center, Beaverton 97006.
P R Health Sci J. 1989 Apr;8(1):107-10.
Macaca mulatta on Cayo Santiago (CS) were examined with intravenous glucose tolerance tests (IV-GTT) for evidence of abnormalities in glucose clearance and insulin secretion. About 10% of the 98 monkeys had impaired glucose clearance associated with impaired insulin secretion. Another 6% had either fasting or secretory hyperinsulinemia with slightly increased rates of glucose clearance, and 20% had low insulin secretion, but no significant changes in glucose clearance. Results were compared to those obtained with CS-derived monkeys tested at Sabana Seca (SS). Glucose clearance per amount of insulin secreted was 40% more effective among CS macaques than among those at SS. There were no differences in weight between impaired and control macaques on CS. Effects of genetics, physical activity, and food consumption can be studied among these macaques and results related to similar metabolic abnormalities in prediabetic and diabetic human beings.
对圣地亚哥岛（CS）上的猕猴进行了静脉葡萄糖耐量试验（IV-GTT），以检查葡萄糖清除和胰岛素分泌异常的证据。在98只猴子中，约10%的猴子存在与胰岛素分泌受损相关的葡萄糖清除受损。另外6%的猴子有空腹或分泌性高胰岛素血症，葡萄糖清除率略有增加，20%的猴子胰岛素分泌较低，但葡萄糖清除无显著变化。将结果与在萨瓦纳塞卡（SS）测试的源自CS的猴子的结果进行了比较。CS猕猴每分泌单位胰岛素的葡萄糖清除效率比SS的猕猴高40%。CS上受损猕猴和对照猕猴的体重没有差异。可以在这些猕猴中研究遗传、身体活动和食物消耗的影响，并将结果与糖尿病前期和糖尿病患者类似的代谢异常相关联。
