Jelínek R, Peterka M
Cleft Palate J. 1977 Jul;14(3):211-21.
Growth changes associated with formation of the secondary palate were studied in H-Velaz mouse embryos by morphometric measurement of medial sagittal sections of the heads between days 13 and 15 of embryonic development. Horizontalization of the palatine processes depends primarily on the length of the mandible and is effected by a shift of palatine process material into the supralingual space. The administration of 7.5 mg cortisone acetate im to the female on day 12, of 0.5 mg 6-aminonicotinamide im on day 14, or amniocentesis on day 14 significantly retards growth of the embryo in general and of the mandible in particular without significantly affecting deflexion of the skull base. The different spatial conditions created by disproportion between deflexion of the base and the length of the mandible cause irregularities in the course of horizontalization which lead, as a rule, to cleft palate.
通过对胚胎发育第13至15天之间头部矢状中切面进行形态测量，研究了H-Velaz小鼠胚胎中与继发腭形成相关的生长变化。腭突的水平化主要取决于下颌骨的长度，并通过腭突物质向舌上间隙的转移来实现。在第12天给雌性小鼠腹腔注射7.5mg醋酸可的松，在第14天注射0.5mg 6-氨基烟酰胺，或在第14天进行羊膜穿刺术，一般会显著延缓胚胎生长，尤其是下颌骨的生长，而对颅底的弯曲没有显著影响。颅底弯曲与下颌骨长度之间的比例失调所造成的不同空间条件，会导致水平化过程出现不规则情况，通常会导致腭裂。
