Gundlach-Graham Alexander, Günther Detlef
Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093, Zurich, Switzerland.
Anal Bioanal Chem. 2016 Apr;408(11):2687-95. doi: 10.1007/s00216-015-9251-8. Epub 2016 Jan 11.
We describe trends in fast, high resolution elemental imaging by laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS). Recently developed low dispersion LA cells deliver quantitative transport of ablated aerosols within 10 ms and also provide enhanced sensitivity compared to conventional LA cells because the analyte ion signal becomes less diluted during aerosol transport. When connected to simultaneous ICPMS instruments, these low dispersion LA cells offer a platform for high speed and high lateral resolution shot-resolved LA-ICPMS imaging. Here, we examine the current paradigms of LA-ICPMS imaging and discuss how newly developed LA cell technology combined with simultaneous ICPMS instrumentation is poised to overcome current instrumental limitations to deliver faster, higher resolution elemental imaging.
我们描述了通过激光烧蚀-电感耦合等离子体质谱法(LA-ICPMS)进行快速、高分辨率元素成像的趋势。最近开发的低分散度LA池可在10毫秒内实现烧蚀气溶胶的定量传输,并且与传统LA池相比,灵敏度有所提高,因为在气溶胶传输过程中分析物离子信号稀释程度降低。当与同步ICPMS仪器连接时,这些低分散度LA池为高速和高横向分辨率的逐点解析LA-ICPMS成像提供了一个平台。在此,我们研究了LA-ICPMS成像的当前模式,并讨论了新开发的LA池技术与同步ICPMS仪器相结合如何有望克服当前仪器的局限性,以实现更快、更高分辨率的元素成像。