Thermo Fisher Scientific Bremen GmbH , Hanna-Kunath Strasse 11 , 28199 Bremen , Germany.
Department of Chemistry , Loughborough University , Loughborough , Leicestershire LE11 3TU , U.K.
Anal Chem. 2018 Oct 2;90(19):11564-11571. doi: 10.1021/acs.analchem.8b02896. Epub 2018 Sep 12.
The introduction of rapid response laser ablation cells and sample transport technologies to laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) has enabled signal pulse durations for a single laser ablation shot of less than 10 ms. These developments have resulted in marked improvements in analytical throughput, resolution, and sensitivity vital for the generation of large, highly spatially resolved elemental maps. The focus on mapping, particularly bioimaging, has obscured the possibility of applying the sensitivity advantage of rapid response technologies to other LA-ICPMS applications, such as high-precision isotope ratio analysis on multicollector (MC) ICPMS. In this work a commercially available rapid response sample transport system and a conventional configuration were compared for LA-MC-ICPMS analysis. Ablation of known reference materials demonstrated "sensitivity" or sample ion yield of 7-9% using the rapid response sample transport system, more than double that for the conventional setup. This increase in efficiency was demonstrated to improve precision for the Pb isotope ratio analysis of the MPI-DING reference glasses and improve the spatial resolution of Hf isotope ratio analysis of reference zircons.
快速响应激光烧蚀细胞和样品传输技术的引入使激光烧蚀电感耦合等离子体质谱（LA-ICPMS）单次激光烧蚀的信号脉冲持续时间小于 10 毫秒。这些发展显著提高了分析通量、分辨率和灵敏度，这对于生成大型、高空间分辨率元素图谱至关重要。对映射的关注，特别是生物成像，掩盖了将快速响应技术的灵敏度优势应用于其他 LA-ICPMS 应用的可能性，例如多收集器（MC）ICPMS 上的高精度同位素比分析。在这项工作中，比较了一种商业上可用的快速响应样品传输系统和传统配置在 LA-MC-ICPMS 分析中的性能。使用快速响应样品传输系统，对已知参考材料的烧蚀显示出 7-9%的“灵敏度”或样品离子产率，是传统设置的两倍多。这种效率的提高被证明可以提高 MPI-DING 参考玻璃中 Pb 同位素比分析的精度，并提高参考锆石中 Hf 同位素比分析的空间分辨率。
