Mendes P H C, Martelli D R B, de Melo Costa S, Gonçalves E, Macedo C P, Silveira M F, Martelli Júnior H
Health Science Program, State University of Montes Claros, Montes Claros, Brazil.
Medicine School, State University of Montes Claros, Montes Claros, Brazil.
Prostate Cancer Prostatic Dis. 2016 Mar;19(1):107-10. doi: 10.1038/pcan.2015.62. Epub 2016 Jan 12.
Digit ratio (2D:4D) has been suggested as a proxy biomarker for prenatal androgen activity and has been linked to prostate cancer, as the genes that regulate the formation and differentiation of the fingers are also related to the carcinogenesis of prostate cancer. To investigate the possible correlation between right hand, left hand and right hand minus left hand (DR-L) 2D:4D and prostate cancer of Brazilian subjects by comparing 2D:4D ratios of individuals diagnosed with prostate cancer and individuals without the disease. Also, to inquire the relationship between 2D:4D and severity of prostate cancer through Gleason scores.
Digital measurements of the lengths of the index and ring fingers of both hands of patients diagnosed with prostate cancer (PCA group, n=100) and healthy control individuals (n=100) were obtained using a digital vernier caliper. Means of the 2D:4D ratios were compared. Data were analyzed by the Student's t-test for unpaired samples, Mann-Whitney test and Spearman's correlation with a significance level of 5%.
The PCA group presented significantly lower right and left 2D:4D (P=0.001 and P=0.002, respectively) in comparison to healthy controls, but DR-L were not significantly different between groups (P=0.589). In addition, digit ratios were not correlated to Gleason score for either hand or in DR-L.
2D:4D seems to be a marker for screening patients for prostate cancer in an admixed population, as males with prostate cancer present lower 2D:4D than healthy subjects. On the other hand, 2D:4D does not appear to be associated with the severity of prostate cancer.
指长比（2D:4D）已被提议作为产前雄激素活性的替代生物标志物，并且与前列腺癌有关，因为调节手指形成和分化的基因也与前列腺癌的致癌作用相关。通过比较被诊断患有前列腺癌的个体和未患该疾病个体的2D:4D比值，来研究巴西受试者右手、左手以及右手减去左手（DR-L）的2D:4D与前列腺癌之间可能存在的相关性。此外，通过 Gleason 评分来探究2D:4D与前列腺癌严重程度之间的关系。
使用数字游标卡尺对被诊断患有前列腺癌的患者（PCA组，n = 100）和健康对照个体（n = 100）双手的食指和无名指长度进行数字测量。比较2D:4D比值的均值。数据采用非配对样本的 Student's t检验、Mann-Whitney检验和Spearman相关性分析，显著性水平为5%。
与健康对照组相比，PCA组右手和左手的2D:4D均显著更低（分别为P = 0.001和P = 0.002），但两组之间的DR-L没有显著差异（P = 0.589）。此外，无论是单手还是DR-L，指长比与Gleason评分均无相关性。
在混合人群中，2D:4D似乎是前列腺癌筛查的一个标志物，因为患有前列腺癌的男性其2D:4D低于健康受试者。另一方面，2D:4D似乎与前列腺癌严重程度无关。
