Lundsgaard C, Matzke A E
Ugeskr Laeger. 1989 Jun 26;151(26):1676-9.
A prospective double-blind cross-over investigation was undertaken among 46 geriatric patients (62-92 years) in which either 5 mg nitrazepam or 1 mg lorazepam were administered as hypnotics for two periods of ten days. No significant differences were observed in the quality of sleep but the objective psychomotor tests and the patients' subjective experience of hang-overs showed that there were significant differences in the frequencies of side effects in favour of lorazepam. It is concluded that daytime sedation after repetitive administration of a benzodiazepine preparation depends upon the half-life and that side effects are revealed better by psychomotor tests than by intellectual, cognitive tests and that lorazepam should be given preference to nitrazepam as a hypnotic for elderly patients.
对46名老年患者（62 - 92岁）进行了一项前瞻性双盲交叉研究，分别给予5毫克硝西泮或1毫克劳拉西泮作为催眠药，为期两个十天疗程。睡眠质量方面未观察到显著差异，但客观心理运动测试及患者对宿醉的主观体验表明，在副作用发生率上，劳拉西泮有显著优势。得出的结论是，重复给予苯二氮䓬类制剂后的日间镇静作用取决于半衰期，心理运动测试比智力、认知测试更能揭示副作用，并且作为老年患者的催眠药，应优先选择劳拉西泮而非硝西泮。
