Manegold-Brauer Gwendolin, Oseledchyk Anton, Floeck Anne, Berg Christoph, Gembruch Ulrich, Geipel Annegret
Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Department of Prenatal Medicine and Gynecologic Ultrasound, University of Basel, Basel, Switzerland.
BMC Pregnancy Childbirth. 2016 Jan 12;16:3. doi: 10.1186/s12884-016-0797-z.
The aim of the study was to report the prevalence and associated findings of fetal ventriculomegaly between 11 + 0 and 13 + 6 gestational weeks and to evaluate a sonographic approach to classify first trimester ventriculomegaly in the standard axial plane used for biparietal diameter (BPD) measurement.
The ratio between choroid plexus and lateral ventricle diameter (PDVDR), between the choroid plexus and lateral ventricle length (PLVLR) and between the choroid plexus and lateral ventricle area (PAVAR) were calculated from stored 2D images of the axial head plane in 100 normal fetuses and 17 fetuses with ventriculomegaly.
The PDVDR, the PLVLR and the PAVAR were below the 5(th) percentile in 82.4%, 94.1% and 94.1% of the cases with ventriculomegaly. Ventriculomegaly was isolated in 29.4% and associated with further anomalies in 70.6% at the initial evaluation. The mean PLVLR in euploid compared to aneuploid fetuses was significantly lower (0.40 versus 0.53 (p = 0.0332)).
The measurements of PDVDR, PLVLR and PAVAR are helpful to objectify ventriculomegaly at 11-14 gestational weeks. The PLVLR and PAVAR were superior to PDVDR, since there seems to be rather shrinkage of the choroid plexus than an increased width of the lateral ventricles in the first trimester.
本研究的目的是报告孕11 + 0至13 + 6周胎儿脑室扩大的患病率及相关发现，并评估一种超声检查方法，以在用于测量双顶径（BPD）的标准轴平面上对孕早期脑室扩大进行分类。
从100例正常胎儿和17例脑室扩大胎儿的头部轴平面二维图像中计算脉络丛与侧脑室直径之比（PDVDR）、脉络丛与侧脑室长度之比（PLVLR）以及脉络丛与侧脑室面积之比（PAVAR）。
在脑室扩大的病例中，PDVDR、PLVLR和PAVAR分别在82.4%、94.1%和94.1%的病例中低于第5百分位数。在初次评估时，29.4%的脑室扩大为孤立性，70.6%与其他异常相关。与非整倍体胎儿相比，整倍体胎儿的平均PLVLR显著更低（0.40对0.53（p = 0.0332））。
PDVDR、PLVLR和PAVAR的测量有助于在孕11 - 14周客观化脑室扩大情况。PLVLR和PAVAR优于PDVDR，因为在孕早期似乎是脉络丛缩小而非侧脑室增宽。
