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使用最大似然期望最大化算法直接重建临床直线加速器的源强度分布。

Direct reconstruction of the source intensity distribution of a clinical linear accelerator using a maximum likelihood expectation maximization algorithm.

作者信息

Papaconstadopoulos P, Levesque I R, Maglieri R, Seuntjens J

机构信息

McGill University, Medical Physics Unit and the Research Institute of the McGill University Health Centre, Montreal, QC H3A 0G4, Canada.

出版信息

Phys Med Biol. 2016 Feb 7;61(3):1078-94. doi: 10.1088/0031-9155/61/3/1078. Epub 2016 Jan 13.

DOI:10.1088/0031-9155/61/3/1078
PMID:26758232
Abstract

Direct determination of the source intensity distribution of clinical linear accelerators is still a challenging problem for small field beam modeling. Current techniques most often involve special equipment and are difficult to implement in the clinic. In this work we present a maximum-likelihood expectation-maximization (MLEM) approach to the source reconstruction problem utilizing small fields and a simple experimental set-up. The MLEM algorithm iteratively ray-traces photons from the source plane to the exit plane and extracts corrections based on photon fluence profile measurements. The photon fluence profiles were determined by dose profile film measurements in air using a high density thin foil as build-up material and an appropriate point spread function (PSF). The effect of other beam parameters and scatter sources was minimized by using the smallest field size ([Formula: see text] cm(2)). The source occlusion effect was reproduced by estimating the position of the collimating jaws during this process. The method was first benchmarked against simulations for a range of typical accelerator source sizes. The sources were reconstructed with an accuracy better than 0.12 mm in the full width at half maximum (FWHM) to the respective electron sources incident on the target. The estimated jaw positions agreed within 0.2 mm with the expected values. The reconstruction technique was also tested against measurements on a Varian Novalis Tx linear accelerator and compared to a previously commissioned Monte Carlo model. The reconstructed FWHM of the source agreed within 0.03 mm and 0.11 mm to the commissioned electron source in the crossplane and inplane orientations respectively. The impact of the jaw positioning, experimental and PSF uncertainties on the reconstructed source distribution was evaluated with the former presenting the dominant effect.

摘要

对于小射野束流建模而言,直接确定临床直线加速器的源强分布仍是一个具有挑战性的问题。当前技术大多需要特殊设备,且在临床中难以实施。在本研究中,我们提出一种利用小射野和简单实验装置的最大似然期望最大化(MLEM)方法来解决源重建问题。MLEM算法迭代地将光子从源平面光线追踪至出射平面,并根据光子注量剖面测量提取校正值。光子注量剖面通过在空气中使用高密度薄箔作为积累材料和合适的点扩散函数(PSF)进行剂量剖面胶片测量来确定。通过使用最小射野尺寸([公式:见原文]平方厘米),将其他束流参数和散射源的影响降至最低。在此过程中,通过估计准直器钳口的位置来再现源遮挡效应。该方法首先针对一系列典型加速器源尺寸的模拟进行基准测试。重建的源在半高宽(FWHM)处相对于入射到靶上的相应电子源的精度优于0.12毫米。估计的钳口位置与预期值在0.2毫米内一致。还在瓦里安诺瓦利斯Tx直线加速器上对测量结果测试了该重建技术,并与先前调试的蒙特卡罗模型进行了比较。重建的源在横向和纵向方向上的FWHM分别与调试的电子源在0.03毫米和0.11毫米内一致。评估了钳口定位、实验和PSF不确定性对重建源分布的影响,其中前者呈现出主导效应。

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