白塞病中的血清白细胞介素-17A
Serum IL-17A in Behçet's disease.
作者信息
Emiroglu Nazan, Cengiz Fatma Pelin, Erdem Gul Bahar
机构信息
Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey. Head of the Department: Prof. Nahide Onsun MD, PhD.
Department of Microbiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. Head of the Department: Dr. U. Gul Bahar Erdem.
出版信息
Postepy Dermatol Alergol. 2015 Oct;32(5):358-61. doi: 10.5114/pdia.2015.54745. Epub 2015 Oct 29.
INTRODUCTION
Behçet's disease is a chronic multisystem disease with spontaneous remissions and relapses. Several studies show that autoimmune mechanisms play an important role in the development of Behçet's disease. Activation of T cells and neutrophils is important in the pathogenesis of the disease. Interleukin 17 (IL-17) is a new cytokine that induces several types of cells to secrete proinflammatory cytokines in many inflammatory and autoimmune diseases.
AIM
This study evaluated the serum levels of IL-17A in active and stable Behçet's disease patients.
MATERIAL AND METHODS
Seventy-six patients who had active clinic findings of Behçet's disease were enrolled in our study. Seventy age- and sex-matched controls were also enrolled. Serum IL-17 levels were studied in peripheral venous blood samples.
RESULTS
No significant differences were found between active Behçet's disease patients and controls in terms of serum IL-17A (p > 0.05).
CONCLUSIONS
These results suggest that IL-17A serum levels do not play an important role in active Behçet's disease.
引言
白塞病是一种具有自发缓解和复发特点的慢性多系统疾病。多项研究表明，自身免疫机制在白塞病的发展中起重要作用。T细胞和中性粒细胞的激活在该疾病的发病机制中至关重要。白细胞介素17（IL-17）是一种新的细胞因子，在许多炎症和自身免疫性疾病中可诱导多种类型的细胞分泌促炎细胞因子。
目的
本研究评估活动期和稳定期白塞病患者血清IL-17A水平。
材料与方法
本研究纳入了76例有白塞病活动期临床症状的患者。还纳入了70例年龄和性别匹配的对照。对外周静脉血样本中的血清IL-17水平进行了研究。
结果
活动期白塞病患者与对照组之间的血清IL-17A水平无显著差异（p>0.05）。
结论
这些结果表明，IL-17A血清水平在活动期白塞病中不起重要作用。
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