白塞病胃肠道受累中存在 Th1 反应而非 Th17 反应。
A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease.
机构信息
Dipartimento Biomedico di Medicina Interna e Specialistica, Palermo University School of Medicine, Palermo, Italy.
出版信息
Clin Exp Rheumatol. 2010 Jul-Aug;28(4 Suppl 60):S27-30. Epub 2010 Sep 23.
OBJECTIVES
Behçet's disease has been historically classified as a Th1 disease. The recently described IL-17/IL-23 pathway seems to play an important role in many inflammatory diseases and in the intestinal abnormalities of AS and CD. The aim of the present study was to evaluate the IL-17/IL-23 axis in parallel with Th1 and IL-27 response in the intestine of patients with BD and gastrointestinal abnormalities.
METHODS
Quantitative TaqMan reverse transcriptase-polymerase chain reaction (RT-PCR) was utilised for all determinations on ileal biopsy specimens obtained from BD, AS and CD patients. The serum levels of Th1 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay.
RESULTS
A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease.
CONCLUSIONS
Although BD shares clinical manifestations with both CD and AS, the immunologic abnormalities seen in the intestine are quite different, indicating that other immune mechanisms should be taken into account.
目的
贝赫切特病（Behcet's disease）既往被归类为 Th1 疾病。最近描述的 IL-17/IL-23 途径似乎在许多炎症性疾病以及 AS 和 CD 的肠道异常中发挥重要作用。本研究旨在评估 Behcet's 病和胃肠道异常患者肠道中 IL-17/IL-23 轴与 Th1 和 IL-27 反应的相关性。
方法
利用定量 TaqMan 逆转录聚合酶链反应（RT-PCR）对从 Behcet's 病、AS 和 CD 患者获得的回肠活检标本进行所有测定。通过酶联免疫吸附试验评估 Th1 和 Th17 细胞因子的血清水平。
结果
在 Behcet's 病的胃肠道受累中存在 Th1 反应，但不存在 Th17 反应。
结论
尽管 Behcet's 病与 CD 和 AS 具有临床表现上的相似性，但在肠道中观察到的免疫异常却截然不同，这表明应考虑其他免疫机制。
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