Wilmer Eye Institute at Johns Hopkins Hospital, Baltimore, Maryland USA.
Whiting School of Engineering, Johns Hopkins University, Baltimore, MD USA.
Mil Med Res. 2016 Jan 11;3:2. doi: 10.1186/s40779-016-0069-2. eCollection 2016.
Indirect traumatic optic neuropathy (ITON) refers to optic nerve injury resulting from impact remote to the optic nerve. The mechanism of injury is not understood, and there are no confirmed protocols for prevention, mitigation or treatment. Most data concerning this condition comes from case series of civilian patients suffering blunt injury, such as from sports- or motor vehicle-related concussion, rather than military-related ballistic or blast damage. Research in this field will likely require the development of robust databases to identify patients with ITON and follow related outcomes, in addition to both in-vivo animal and virtual human models to study the mechanisms of damage and potential therapies.
间接性外伤性视神经病变(ITON)是指由于视神经以外的部位受到撞击而导致的视神经损伤。其损伤机制尚不清楚,也没有针对预防、减轻或治疗的既定方案。关于这种疾病的大多数数据都来自于非军事性钝伤患者的病例系列研究,如与运动或机动车相关的震荡,而非与军事相关的弹道或爆炸损伤。这一领域的研究可能需要开发强大的数据库来识别患有 ITON 的患者并跟踪相关结果,此外还需要体内动物和虚拟人类模型来研究损伤机制和潜在的治疗方法。