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[间接性外伤性视神经病变——诊断中的问题与挑战以及治疗中的不确定性]

[Indirect traumatic optic neuropathy--problems and challenges in diagnosis and uncertainty in treatment].

作者信息

Kesler Anat, Feinsod Moshe

机构信息

Neuro-Ophthalmology Unit, Department of Ophthalmology Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

出版信息

Harefuah. 2004 May;143(5):359-63, 390.

Abstract

Traumatic optic neuropathy is one of the many facets of head injuries and a major cause of devastating permanent visual loss due to head injuries. Indirect traumatic optic neuropathy (ITON) occurs when blunt trauma to the forehead results in a transmission of force through the cranium to the confined portion of the optic nerve within the bony optic canal. The physics of the injuring forces that induced anatomical and histological effects on the optic nerve were thoroughly studied but the recognition of ITON in the acute stage still poses a diagnostic challenge. The accuracy of diagnosis still varies ten-fold among different centers. The use of Visual Evoked Potentials (VEP) in the evaluation of patients at risk of ITON will improve the diagnostic abilities. The clinical course varies between immediate and permanent visual loss of varied severity, delayed deterioration and spontaneous recovery. No clinical technique, however, proved to provide predictive abilities. None of the current forms of treatment--conservative, high dose steroids and surgical decompression of optic nerve, were found to be superior, and the patient series are still too small. The reviewers recommend establishing a national registry of ITON that will facilitate the improvement of the diagnosis and will contribute to the adoption of an evidence-based therapeutic approach.

摘要

创伤性视神经病变是头部损伤的诸多方面之一,也是头部损伤导致严重永久性视力丧失的主要原因。间接创伤性视神经病变(ITON)发生于前额受到钝性创伤时,外力通过颅骨传递至骨性视神经管内视神经的受限部分。人们对对视神经产生解剖学和组织学影响的致伤力的物理原理进行了深入研究,但在急性期识别ITON仍然是一项诊断挑战。不同中心的诊断准确率仍相差十倍。使用视觉诱发电位(VEP)评估有ITON风险的患者将提高诊断能力。临床病程差异很大,从即刻出现不同严重程度的永久性视力丧失、延迟性恶化到自发恢复。然而,尚无临床技术被证明具有预测能力。目前的各种治疗方法——保守治疗、大剂量类固醇治疗以及视神经减压手术,均未显示出优势,而且相关患者系列数量仍然太少。综述作者建议建立一个全国性的ITON登记系统,这将有助于改善诊断,并有助于采用基于证据的治疗方法。

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