前列腺癌中的腿部酒精反应性动作性肌阵挛：一种新型副肿瘤综合征？
Alcohol-responsive Action Myoclonus of the Leg in Prostate Cancer: A Novel Paraneoplastic Syndrome?
作者信息
Termsarasab Pichet, Frucht Steven J
机构信息
Movement Disorder Division, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Neurology Division, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Movement Disorder Division, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2015 Dec 22;5:357. doi: 10.7916/D80G3JSX. eCollection 2015.
BACKGROUND
Paraneoplastic movement disorders in prostate cancer are rare, and to our knowledge paraneoplastic myoclonus has not previously been reported.
CASE REPORT
We report two men with adenocarcinoma of the prostate who developed isolated alcohol-responsive action myoclonus of one leg. Myoclonus was absent at rest but triggered by movement, standing, or walking. Evaluations excluded malignant invasion of the nervous system, and testing for commercial paraneoplastic antibodies in serum and cerebrospinal fluid were unrevealing. Both patients experienced significant improvement with alcohol, and sodium oxybate was used in one patient with good initial benefit.
DISCUSSION
Alcohol-responsive leg myoclonus might be a novel paraneoplastic syndrome associated with prostate cancer. The nature of the syndrome and the source of the myoclonus are currently unknown.
背景
前列腺癌相关的副肿瘤性运动障碍较为罕见，据我们所知，此前尚未有副肿瘤性肌阵挛的报道。
病例报告
我们报告了两名前列腺腺癌男性患者，他们出现了单腿孤立性酒精反应性动作性肌阵挛。静息时无肌阵挛，但运动、站立或行走时会诱发。评估排除了神经系统的恶性浸润，血清和脑脊液中商业化副肿瘤抗体检测均未发现异常。两名患者饮酒后均有显著改善，其中一名患者使用羟丁酸钠初始效果良好。
讨论
酒精反应性腿部肌阵挛可能是一种与前列腺癌相关的新型副肿瘤综合征。目前该综合征的性质及肌阵挛的来源尚不清楚。
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