链脲佐菌素诱导的糖尿病降低了大鼠心脏膜中[125I] - 内皮素结合位点的密度。
Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.
作者信息
Nayler W G, Liu J J, Panagiotopoulos S, Casley D J
机构信息
Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
出版信息
Br J Pharmacol. 1989 Aug;97(4):993-5. doi: 10.1111/j.1476-5381.1989.tb12552.x.
Abstract
The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity.
摘要
测定了急性链脲佐菌素诱导的糖尿病对大鼠心脏膜碎片中[125I] - 内皮素（[125I] - ET）特异性高亲和力结合位点的亲和力（KD）、密度（Bmax）和选择性的影响。单次静脉推注链脲佐菌素（60 mg·kg-1）三天后，[125I]ET结合位点的密度降低（P < 0.01），而亲和力或选择性无变化。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan.链脲佐菌素或四氧嘧啶诱导的糖尿病代谢异常比较。
Lancet. 1968 Mar 30;1(7544):670-1. doi: 10.1016/s0140-6736(68)92103-x.
3
Hearts from diabetic rats are more resistant to in vitro ischemia: possible role of altered Ca2+ metabolism.糖尿病大鼠的心脏对体外缺血更具耐受性：Ca2+代谢改变的潜在作用。
Circ Res. 1988 May;62(5):931-40. doi: 10.1161/01.res.62.5.931.
4
Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells.内皮素可刺激培养的血管平滑肌细胞中的磷脂酶C。
Biochem Biophys Res Commun. 1988 Dec 30;157(3):1360-8. doi: 10.1016/s0006-291x(88)81025-8.
5
Endothelin has potent inotropic effects in rat atria.内皮素对大鼠心房具有强大的变力作用。
Eur J Pharmacol. 1988 Dec 13;158(3):275-8. doi: 10.1016/0014-2999(88)90079-9.
6
Endothelin, a novel vasoconstrictor peptide, as potent bronchoconstrictor.内皮素是一种新型血管收缩肽，也是一种强效支气管收缩剂。
Eur J Pharmacol. 1988 Sep 13;154(2):227-8. doi: 10.1016/0014-2999(88)90106-9.
7
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