幼儿期逆境与妊娠结局
Early Childhood Adversity and Pregnancy Outcomes.
作者信息
Smith Megan V, Gotman Nathan, Yonkers Kimberly A
机构信息
Department of Psychiatry, Yale School of Medicine, 142 Temple Street, Suite #301, New Haven, CT, 06510, USA.
出版信息
Matern Child Health J. 2016 Apr;20(4):790-8. doi: 10.1007/s10995-015-1909-5.
Abstract
OBJECTIVES
To examine the association between adverse childhood experiences (ACEs) and pregnancy outcomes; to explore mediators of this association including psychiatric illness and health habits.
METHODS
Exposure to ACEs was determined by the Early Trauma Inventory Self Report Short Form; psychiatric diagnoses were generated by the Composite International Diagnostic Interview administered in a cohort of 2303 pregnant women. Linear regression and structural equation modeling bootstrapping approaches tested for multiple mediators.
RESULTS
Each additional ACE decreased birth weight by 16.33 g and decreased gestational age by 0.063. Smoking was the strongest mediator of the effect on gestational age.
CONCLUSIONS
ACEs have an enduring effect on maternal reproductive health, as manifested by mothers' delivery of offspring that were of reduced birth weight and shorter gestational age.
摘要
目的
研究童年不良经历（ACEs）与妊娠结局之间的关联；探索这种关联的中介因素，包括精神疾病和健康习惯。
方法
通过早期创伤问卷自我报告简表确定ACEs暴露情况；采用复合国际诊断访谈对2303名孕妇进行队列研究以得出精神疾病诊断。使用线性回归和结构方程模型自抽样法对多个中介因素进行检验。
结果
每增加一次ACE，出生体重降低16.33克，孕周缩短0.063周。吸烟是对孕周影响最大的中介因素。
结论
ACEs对孕产妇生殖健康有持久影响，表现为母亲所分娩的后代出生体重降低、孕周缩短。
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