Department of Morphology & Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.
Laboratory of Integrative Neuroscience (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil.
Epigenomics. 2024;16(19-20):1273-1286. doi: 10.1080/17501911.2024.2401318. Epub 2024 Oct 9.
Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) may play a regulatory role in this process. This study investigates the relationship between maternal exposure to CM and miRNA expression in maternal and perinatal tissues. We enrolled 43 pregnant women and assessed their CM exposure. We collected maternal blood, cord blood and placental tissue samples during childbirth and performed miRNA profiling using next generation sequencing. Maternal CM was inversely associated with hsa-miR-582-3p levels in cord blood. Pathway analysis revealed that this miRNA regulates genes involved in intrauterine development. Our findings highlight the potential impact of maternal CM exposure on offspring epigenetic mechanisms.
儿童虐待（CM）不仅可能直接影响到受虐待者本人，还可能影响到他们的后代。然而，其中的生物学机制尚不清楚。微小 RNA（miRNA）可能在这一过程中发挥调节作用。本研究旨在探讨母体遭受 CM 与产妇和围产期组织中 miRNA 表达之间的关系。我们纳入了 43 名孕妇，并评估了她们的 CM 暴露情况。我们在分娩期间采集了母亲的血液、脐血和胎盘组织样本，并使用下一代测序进行了 miRNA 谱分析。母体 CM 与脐血中的 hsa-miR-582-3p 水平呈负相关。通路分析表明，这种 miRNA 调节了与宫内发育相关的基因。我们的研究结果强调了母体 CM 暴露对后代表观遗传机制的潜在影响。
