分泌型卷曲相关蛋白 2（sFRP2）作为一种促黑素生成剂的功能；sFRP2 在 UV 诱导的色素沉着障碍中的作用。

Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders.

机构信息

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, Ajou University School of Medicine, Suwon, Korea.

Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

出版信息

J Invest Dermatol. 2016 Jan;136(1):236-44. doi: 10.1038/JID.2015.365.

DOI:10.1038/JID.2015.365

PMID:26763443

Abstract

In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via β-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.

摘要

在这项研究中，我们发现分泌型卷曲相关蛋白 2（sFRP2）在黄褐斑和光化性黑子的色素沉着皮肤以及急性紫外线照射的皮肤中过度表达。为了研究 sFRP2 对黑素生成的影响，我们用 sFRP2 慢病毒或 sh-sFRP2 感染正常人黑素细胞。结果发现 sFRP2 通过β-连环蛋白信号通路上调小眼畸形相关转录因子和/或酪氨酸酶来刺激黑素生成。在与成纤维细胞共培养的黑素细胞和离体培养的皮肤中进一步证实了 sFRP2 在色素沉着中的刺激作用。这些发现表明 sFRP2 作为一种促黑素生成剂发挥作用，并在紫外线诱导的色素沉着障碍的发展中发挥作用。