Hirobe Tomohisa
Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Int J Mol Sci. 2024 Apr 22;25(8):4560. doi: 10.3390/ijms25084560.
Mammalian melanin is produced in melanocytes and accumulated in melanosomes. Melanogenesis is supported by many factors derived from the surrounding tissue environment, such as the epidermis, dermis, and subcutaneous tissue, in addition to numerous melanogenesis-related genes. The roles of these genes have been fully investigated and the molecular analysis has been performed. Moreover, the role of paracrine factors derived from epidermis has also been studied. However, the role of dermis has not been fully studied. Thus, in this review, dermis-derived factors including soluble and insoluble components were overviewed and discussed in normal and abnormal circumstances. Dermal factors play an important role in the regulation of melanogenesis in the normal and abnormal mammalian skin.
哺乳动物的黑色素在黑素细胞中产生，并积聚在黑素小体中。除了众多与黑色素生成相关的基因外，黑色素生成还受到来自周围组织环境（如表皮、真皮和皮下组织）的许多因素的支持。这些基因的作用已得到充分研究，并进行了分子分析。此外，表皮衍生的旁分泌因子的作用也已得到研究。然而，真皮的作用尚未得到充分研究。因此，在本综述中，对包括可溶性和不可溶性成分在内的真皮衍生因子在正常和异常情况下进行了概述和讨论。真皮因子在正常和异常哺乳动物皮肤的黑色素生成调节中起着重要作用。
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