Morales-Bozo Irene, Ortega-Pinto Ana, Rojas Alcayaga Gonzalo, Aitken Saavedra Juan P, Salinas Flores Olga, Lefimil Puente Claudia, Lozano Moraga Carla, Manríquez Urbina José M, Urzúa Orellana Blanca
Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago, Chile.
Department of Pathology and Oral Medicine, Faculty of Dentistry, University of Chile, Santiago, Chile.
Gerodontology. 2017 Mar;34(1):42-48. doi: 10.1111/ger.12220. Epub 2016 Jan 14.
The aim of this study was to determine the efficacy of a chamomile (Matricaria chamomilla) and linseed (Linum usitatissimum) saliva substitute in the relief of xerostomia in older participants.
In elders, xerostomia is a permanent and progressive condition that significantly affects their quality of life. The treatment for progressive xerostomia is currently restricted to palliative measures, and saliva substitutes are indicated. A lack of evidence on the effectiveness of the saliva substitutes in the relief of symptoms of xerostomia has been reported.
Seventy-four elderly participants presenting xerostomia of diverse origin were selected. Herbal saliva substitute and carboxymethyl cellulose conventional saliva substitute were tested using a double-blind, randomised, cross-sectional clinical trial.
Every participant of the study exhibited dry mouth sensation. A sensation of thick saliva was described in 59.5% of the participants. The need for liquid intake to swallow food, the sensation of difficulty in swallowing and the burning sensation in the tongue were observed in 54.1, 56.8 and 27.0% of the participants, respectively. The most prevalent diseases were hypertension, depressive symptoms and arthritis. Results of the clinical tests showed that the herbal saliva substitute produced a greater relief of dry mouth symptoms, thick saliva sensation and the sensation of difficulty in swallowing than the conventional substitute (Wilcoxon test p < 0.05).
New chamomile- and linseed-based saliva substitute was effective in relieving xerostomia symptoms in older participants of this study.
本研究旨在确定洋甘菊(母菊)和亚麻籽(亚麻)唾液替代品对老年受试者口干症的缓解效果。
在老年人中,口干症是一种持续且渐进性的病症,会显著影响他们的生活质量。目前,针对渐进性口干症的治疗仅限于姑息措施,唾液替代品是适用的。据报道,缺乏关于唾液替代品缓解口干症症状有效性的证据。
选取74名患有不同原因口干症的老年受试者。采用双盲、随机、横断面临床试验对草药唾液替代品和羧甲基纤维素传统唾液替代品进行测试。
本研究的每位受试者均表现出口干感。59.5%的受试者描述有唾液浓稠感。分别有54.1%、56.8%和27.0%的受试者表示需要摄入液体以吞咽食物、有吞咽困难感和舌头有灼烧感。最常见的疾病是高血压、抑郁症状和关节炎。临床试验结果表明,与传统替代品相比,草药唾液替代品在缓解口干症状、唾液浓稠感和吞咽困难感方面效果更佳(Wilcoxon检验p<0.05)。
新型洋甘菊和亚麻籽基唾液替代品对本研究中的老年受试者缓解口干症症状有效。