Berger S A, Dan M, Serour F, Gorea A, Levenberg A, Krispin M
Department of Microbiology, Tel-Aviv Medical Center, Israel.
Chemotherapy. 1989;35(5):326-9. doi: 10.1159/000238689.
Each of 40 patients underwent elective laparotomy following administration of a single 1.0-gram intravenous dose of ceftizoxime, ceftriaxone, cefoperazone or cefotaxime. Therapeutic concentrations of cefoperazone and ceftriaxone were achieved in peritoneal tissue in 20/20 patients. Only 9/20 samples from patients receiving the other two antibiotics had detectable antibiotic activity. The antibiotic concentration in peritoneal fluid (7 samples) was 2.36-11.15 times higher than that of concurrently obtained peritoneal tissue. When adjusted for the in vitro susceptibility (MIC) of potential peritoneal pathogens, our data suggest that ceftriaxone and cefoperazone may be preferable to other third-generation cephalosporins for the prophylaxis and therapy of intraabdominal infection.
40名患者在静脉注射单次1.0克剂量的头孢唑肟、头孢曲松、头孢哌酮或头孢噻肟后均接受了择期剖腹手术。20/20例患者的腹膜组织中达到了头孢哌酮和头孢曲松的治疗浓度。接受其他两种抗生素治疗的患者中，只有9/20的样本具有可检测到的抗生素活性。腹膜液（7个样本）中的抗生素浓度比同时获取的腹膜组织中的抗生素浓度高2.36 - 11.15倍。根据潜在腹膜病原体的体外药敏试验（MIC）进行调整后，我们的数据表明，对于腹腔内感染的预防和治疗，头孢曲松和头孢哌酮可能比其他第三代头孢菌素更具优势。
