Saffitz Jeffrey E, Corradi Domenico
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Department of Biomedical, Biotechnological, and Translational Sciences (S.Bi.Bi.T.), Unit of Pathology, University of Parma, Parma, Italy.
Cardiovasc Pathol. 2016 Mar-Apr;25(2):149-57. doi: 10.1016/j.carpath.2015.11.005. Epub 2015 Dec 2.
This review summarizes progress in the fields of cardiac electrophysiology, arrhythmias and sudden death made in the 25-year interval between 1992 and 2016 during which time Cardiovascular Pathology has been published. Organized along clinical lines, it considers the major heart rhythm disorders underlying atrial, atrioventricular and ventricular arrhythmias, and sudden cardiac death. There is a strong focus on the remarkable advances in understanding the genetic basis for cardiac rhythm disturbances and elucidating fundamental mechanisms of abnormal conduction and impulse formation. During this 25-year period, our understanding of how altered tissue structure (classical pathology) contributes to arrhythmias and sudden death has undergone continuous refinement as new insights have been gained about arrhythmia mechanisms and the dynamic interplay between anatomic substrates and triggers of the major heart rhythm disorders.
本综述总结了1992年至2016年这25年间心脏电生理学、心律失常和猝死领域取得的进展，在此期间《心血管病理学》一直发行。本综述按照临床思路编排，探讨了心房、房室和室性心律失常以及心源性猝死背后的主要心律紊乱。重点聚焦于在理解心律紊乱的遗传基础以及阐明异常传导和冲动形成的基本机制方面取得的显著进展。在这25年期间，随着对心律失常机制以及主要心律紊乱的解剖学基质与触发因素之间动态相互作用有了新的认识，我们对组织结构改变（经典病理学）如何导致心律失常和猝死的理解也在不断完善。
