少即是多：内质网应激与β细胞增殖。
When Less Is Better: ER Stress and Beta Cell Proliferation.
机构信息
Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Development and Aging Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Dev Cell. 2016 Jan 11;36(1):4-6. doi: 10.1016/j.devcel.2015.12.030.
Pancreatic β cells synthesize and secrete insulin to increase anabolic metabolism in an organism, and insulin synthesis has long been suspected to inhibit β cell replication. Recently in Cell Metabolism, Szabat et al. (2015) present evidence that deletion of Insulin genes alleviates ER stress and promotes mature β cell replication.
胰腺β细胞合成并分泌胰岛素以增加机体的合成代谢，长期以来人们一直怀疑胰岛素的合成会抑制β细胞的复制。最近，Szabat 等人（2015）在《细胞代谢》杂志上发表的研究结果表明，胰岛素基因的缺失可减轻内质网应激并促进成熟β细胞的复制。
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