State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2592-5. doi: 10.1002/anie.201511276. Epub 2016 Jan 14.
Multivalent peptide nanofibers have attracted intense attention as promising platforms, but the fabrication of those nanofibers is mainly dependent on the spontaneous assembly of β-sheet peptides. Herein we report an alternative approach to the creation of nanofibers: the polyoxometalate-driven self-assembly of short peptides. The resultant nanofibers with concentrated positive charges are excellent multivalent ligands for binding with bacterial cells and thus lead to a salient improvement in bioactivity.
多价肽纳米纤维作为有前途的平台引起了人们的极大关注，但这些纳米纤维的制造主要依赖于β-折叠肽的自发组装。在此，我们报告了一种创建纳米纤维的替代方法：多酸驱动的短肽自组装。得到的带高浓度正电荷的纳米纤维是与细菌细胞结合的优异多价配体，从而显著提高了生物活性。
