具有扩展测量范围且带有八聚精氨酸作为细胞穿透肽的聚合物pH纳米传感器。
Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide.
作者信息
Ke Peng, Sun Honghao, Liu Mingxing, Su Zhengding, Hu Kanghong, Zhua Hongda, Guo Huilin, Sun Hongmei, Andresen Thomas Lars, Olsen Lars Folke
机构信息
School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
Department for Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, 2800 Lyngby, Denmark.
出版信息
IET Nanobiotechnol. 2016 Feb;10(1):8-12. doi: 10.1049/iet-nbt.2014.0070.
A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.
一种模拟人类免疫缺陷病毒1型Tat蛋白的合成肽八聚精氨酸，被用作新型pH纳米传感器的细胞穿透部分。该纳米传感器通过在同一纳米颗粒中同时掺入两种互补的pH敏感荧光团，表现出增强的细胞摄取能力，以及从pH 3.9到pH 7.3的扩展测量范围。作者认为，这种三重荧光pH传感器为pH测量提供了一种新工具，可应用于细胞摄取机制研究和新型纳米药物设计。
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