Amselem Moisés
Clinica Dr. Moisés Amselem, Madrid, Spain.
Clin Cosmet Investig Dermatol. 2015 Dec 29;9:9-14. doi: 10.2147/CCID.S93137. eCollection 2016.
Nonsurgical esthetic improvement of the upper arms is a desirable goal for many individuals. Radiesse(®) (calcium hydroxylapatite) is an effective dermal filler for a number of indications because of its volumizing effect and the ability to stimulate neocollagenesis. No studies have reported on its safety and effectiveness for the treatment of the upper arm. In a prospective, open-label study, 30 subjects seeking improvement in the esthetic appearance of their upper arms received injections with Radiesse(®) (1.5 mL/arm) at two separate visits, 1 month apart. Subjects returned for a follow-up visit 4 months after the second treatment. The primary endpoint was the degree of overall subject and evaluator (investigators and study nurses) satisfaction assessed using the 5-point Global Satisfaction Scale (ranging from "1" very dissatisfied to "5" very satisfied). Secondary endpoints included assessments of skin quality (flaccidity and volume distribution) using a new Visual Analog Scale for upper arms and overall assessment of treatment using the Global Aesthetic Improvement Scale. All (100%) of both subjects and evaluators were "satisfied" or "very satisfied" with treatment. The mean Global Satisfaction Score for investigators and study nurses was 4.60 and for subjects 4.53 (satisfied to very satisfied). Assessments of flaccidity and volume improved significantly compared with baseline at the post-treatment visit and also between visits. Compared with baseline, 77% of subjects were rated as considerably improved (good or great improvement) by the investigator and study nurse; 73% of subjects rated themselves as considerably improved and 43% of these rated a "great improvement." All stated they would repeat the treatment and recommend it to others. No adverse events were reported. Radiesse(®) is an effective minimally invasive treatment option for improving upper arm contours and was associated with a 100% satisfaction rate for both subjects and evaluators.
对于许多人来说，非手术方式改善上臂外观是一个理想目标。瑞蓝（Radiesse®）（羟基磷灰石钙）因其填充效果和刺激新胶原蛋白生成的能力，是多种适应症的有效真皮填充剂。尚无研究报道其治疗上臂的安全性和有效性。在一项前瞻性、开放标签研究中，30名希望改善上臂美观的受试者在两次单独就诊时接受了瑞蓝（Radiesse®）注射（每只手臂1.5 mL），两次就诊间隔1个月。第二次治疗后4个月，受试者返回进行随访。主要终点是使用5分制全球满意度量表（从“1”非常不满意到“5”非常满意）评估受试者和评估者（研究者和研究护士）的总体满意度。次要终点包括使用新的上臂视觉模拟量表评估皮肤质量（松弛度和体积分布）以及使用全球美学改善量表对治疗进行总体评估。所有受试者和评估者（100%）对治疗“满意”或“非常满意”。研究者和研究护士的平均全球满意度评分为4.60，受试者为4.53（满意到非常满意）。与基线相比，治疗后就诊时以及两次就诊之间，松弛度和体积评估均有显著改善。与基线相比，77%的受试者被研究者和研究护士评为有显著改善（良好或极大改善）；73%的受试者自评有显著改善，其中43%评为“极大改善”。所有受试者均表示会再次接受该治疗并推荐给他人。未报告不良事件。瑞蓝（Radiesse®）是改善上臂轮廓的有效微创治疗选择，受试者和评估者的满意度均为100%。
