Fasano S, Pierantoni R, Minucci S, Di Matteo L, D'Antonio M, Chieffi G
Institute of Biology, I Faculty of Medicine, University of Naples, Italy.
Gen Comp Endocrinol. 1989 Sep;75(3):349-54. doi: 10.1016/0016-6480(89)90169-x.
The effect of a gonadotropin-releasing hormone analog (GnRHA, HOE766) was studied in hypophysectomized elasmobranch fish Torpedo marmorata and T. ocellata. In addition, estradiol (E2) effects were studied in intact and hypophysectomized (HPX) animals. Plasma androgen concentrations were measured 2 or 6 hr after GnRHA (100 ng or 10 micrograms) or 6 hr after E2 (10(-9) or 10(-6) M) intratesticular injections. Both GnRHA and E2 induced the increase of plasma androgen levels in HPX fish. E2 also enhanced androgen levels in intact animals. It is concluded that GnRH-like substances and E2 may modulate testicular activity in elasmobranch fish.
在切除垂体的板鳃亚纲鱼类电鳐和眼斑电鳐中研究了促性腺激素释放激素类似物（GnRHA，HOE766）的作用。此外，还在完整和切除垂体的动物中研究了雌二醇（E2）的作用。在睾丸内注射GnRHA（100 ng或10微克）后2或6小时或E2（10⁻⁹或10⁻⁶ M）后6小时测量血浆雄激素浓度。GnRHA和E2均诱导切除垂体的鱼类血浆雄激素水平升高。E2还提高了完整动物的雄激素水平。得出的结论是，GnRH样物质和E2可能调节板鳃亚纲鱼类的睾丸活动。
