以4天抗逆转录病毒治疗中断衡量的不依从性：在现代抗逆转录病毒治疗时代，抑郁和种族/民族的影响有多大？
Nonadherence as 4-day Antiretroviral Therapy Interruptions: Do Depression and Race/Ethnicity Matter as Much in the Modern Antiretroviral Therapy Era?
作者信息
Sauceda John A, Johnson Mallory O, Saberi Parya
机构信息
Center for AIDS Prevention Studies, University of California, San Francisco, 550 16th Street, 3rd Floor, UCSF Mailcode 0886, San Francisco, CA, 94158, USA.
出版信息
AIDS Behav. 2016 Nov;20(11):2624-2628. doi: 10.1007/s10461-015-1283-8.
Abstract
HIV + White, Latino, and African Americans (N = 1131) completed a survey advertised on social media to re-examine the effect of depressive symptoms (via the Patient Health Questionnaire; PHQ-9) and race/ethnicity on antiretroviral therapy nonadherence (defined as past 3-month, 4-day treatment interruption). An adjusted logistic regression showed a 15 % increase in odds for a treatment interruption per 1-unit increase on the PHQ-9. The effect of depressive symptoms on nonadherence was greater for Latinos (OR = 1.80, p < 0.05), but not for African Americans, compared to Whites. The benefits of modern ART (e.g., simpler, forgiving to minor lapses) may not circumvent the effect of depressive symptomatology.
摘要
1131名感染艾滋病毒的白人、拉丁裔和非裔美国人完成了一项在社交媒体上发布广告的调查，以重新审视抑郁症状（通过患者健康问卷；PHQ - 9）和种族/族裔对抗逆转录病毒治疗不依从性（定义为过去3个月内有4天治疗中断）的影响。调整后的逻辑回归显示，PHQ - 9每增加1个单位，治疗中断的几率增加15%。与白人相比，抑郁症状对拉丁裔不依从性的影响更大（比值比 = 1.80，p < 0.05），但对非裔美国人没有这种影响。现代抗逆转录病毒治疗（如更简单、对小失误宽容）的益处可能无法避免抑郁症状的影响。
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