Division of HIV/AIDS Prevention, DHAP/NCHHSTP/CDC, Centers for Disease Control and Prevention, 1600 Clifton Rd NE MS E-45, Atlanta, GA, 30333, USA.
Cerner Corporation, Kansas City, MO, USA.
AIDS Behav. 2019 Nov;23(11):3015-3023. doi: 10.1007/s10461-019-02494-9.
We assessed disparities in viral suppression (VS) and antiretroviral therapy (ART) adherence among women of the HIV Outpatient Study to inform HIV treatment strategies. We used adjusted prevalence ratios (aPR) with 95% confidence intervals (CI) to assess VS by race/ethnicity and generalized estimating equations to investigate factors associated with not achieving VS and ART non-adherence. Among 426 women (median age = 46 years), at baseline, VS was less prevalent among black women (63%) compared with Hispanic women/Latinas (73%) and white women (78%). In the multivariable analysis, factors significantly associated with not achieving VS included the following social and behavioral determinants of care: using public insurance (aPR = 1.69, CI 1.01-2.82, p = 0.044) compared to using private insurance, seeking care in a public clinic (aPR = 1.60, CI 1.03-2.50, p = 0.037) compared to seeking care in a private clinic, and ART non-adherence (aPR = 2.79, CI 1.81-4.29), p < 0.001). Although race was not a significant factor in not achieving VS, race was associated with ART non-adherence; black women were more likely to miss a dose of ART medication (aPR = 2.07, CI 1.19-3.60, p = 0.010) when compared to white women and Hispanic women/Latinas. Interventions and resources disseminated to address social barriers to care and improve VS and ART adherence among HIV-positive women, particularly black women, are warranted.
我们评估了 HIV 门诊研究中女性的病毒抑制(VS)和抗逆转录病毒治疗(ART)依从性差异,以为 HIV 治疗策略提供信息。我们使用调整后的患病率比(aPR)及其 95%置信区间(CI)来评估种族/民族之间的 VS,并使用广义估计方程来研究与未达到 VS 和 ART 不依从相关的因素。在 426 名女性(中位年龄为 46 岁)中,基线时,黑人女性(63%)的 VS 低于西班牙裔/拉丁裔女性(73%)和白人女性(78%)。在多变量分析中,与未达到 VS 显著相关的因素包括以下与护理相关的社会和行为决定因素:与使用私人保险相比,使用公共保险(aPR=1.69,CI 1.01-2.82,p=0.044),与在私人诊所就诊相比,在公共诊所就诊(aPR=1.60,CI 1.03-2.50,p=0.037),以及 ART 不依从(aPR=2.79,CI 1.81-4.29,p<0.001)。尽管种族不是未达到 VS 的重要因素,但种族与 ART 不依从有关;与白人女性和西班牙裔/拉丁裔女性相比,黑人女性错过一剂 ART 药物的可能性更高(aPR=2.07,CI 1.19-3.60,p=0.010)。需要传播干预措施和资源,以解决护理方面的社会障碍,并提高 HIV 阳性女性,特别是黑人女性的 VS 和 ART 依从性。