细胞外信号调节激酶1和2在癌症治疗中的作用：聚焦于肝细胞癌
Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma.
作者信息
Mehdizadeh Amir, Somi Mohammad Hossein, Darabi Masoud, Jabbarpour-Bonyadi Mortaza
机构信息
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Mol Biol Rep. 2016 Feb;43(2):107-16. doi: 10.1007/s11033-016-3943-9. Epub 2016 Jan 14.
Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.
细胞外信号调节激酶（ERK）通路在癌细胞的存活和增殖中起着至关重要的作用。该信号通路与肝细胞癌（HCC）细胞的上皮-间质转化和耐药性相关，而耐药性是化疗中常见的挑战。因此，该通路的介质最近被认为是HCC的新型治疗靶点。在本综述中，将重点介绍和讨论作为ERK信号通路主要成分的ERK1和ERK2在HCC生物学和耐药性中的作用。
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