Department of Obstetrics and Gynaecology/Department of Research, Sørlandet Hospital, Kristiansand, Norway.
Department of Public Health, Sports and Nutrition, University of Agder, Kristiansand, Norway.
BJOG. 2017 Jan;124(1):97-109. doi: 10.1111/1471-0528.13862. Epub 2016 Jan 14.
To examine whether a lifestyle intervention in pregnancy limits gestational weight gain (GWG) and provides measurable health benefits for mother and newborn.
Randomised controlled trial.
Healthcare clinics of southern Norway.
Healthy, non-diabetic, nulliparous women, aged ≥18 years, with a body mass index of ≥19 kg/m , and with a singleton pregnancy at ≤20 weeks of gestation.
Women were randomised to an intervention group (with dietary counselling twice by telephone and access to twice-weekly exercise groups) or to a control group (with standard prenatal care). Participants were measured three times during pregnancy and at delivery, and newborns were measured at delivery. Hospital records were reviewed for outcomes of pregnancy and delivery. Assessors were blinded to group allocation. Analysis was performed by intention to treat, assessing GWG using the Student's t-test and linear mixed models, and comparing proportions using the chi-square test.
GWG, rates of pregnancy complications and operative deliveries, and newborn birthweight.
A total of 606 women were randomised. Of these, 591 were analysed, with 296 in the intervention group and 295 in the control group. At term, the mean GWG from pre-pregnancy was 14.4 kg for the intervention group and 15.8 kg for the control group (mean difference 1.3 kg; 95% confidence interval, 95% CI 0.3-2.3 kg; P = 0.009). There was no significant difference between groups in the frequency of pregnancy complications or operative deliveries. The intervention demonstrated no effect on the mean birthweight of term infants, or on the proportion of large newborns.
The Norwegian Fit for Delivery lifestyle intervention in pregnancy had no measurable effect on obstetrical or neonatal outcomes, despite a modest but significant decrease in GWG.
Norwegian Fit for Delivery RCT: reduced gestational weight gain, unchanged birthweight and obstetric outcomes.
探讨孕期生活方式干预是否能限制孕妇体重过度增加（GWG），并为母婴提供可衡量的健康益处。
随机对照试验。
挪威南部的医疗保健诊所。
健康、非糖尿病、初产妇，年龄≥18 岁，BMI≥19kg/m²，妊娠 20 周内单胎妊娠。
将孕妇随机分为干预组（电话咨询两次，参加每周两次的锻炼小组）或对照组（接受标准产前护理）。参与者在孕期和分娩时进行了三次测量，新生儿在分娩时进行了测量。对妊娠和分娩结局进行了医院记录回顾。评估人员对分组情况不知情。采用意向治疗进行分析，使用学生 t 检验和线性混合模型评估 GWG，使用卡方检验比较比例。
GWG、妊娠并发症和剖宫产率，以及新生儿出生体重。
共随机分配了 606 名女性。其中，591 名女性进行了分析，干预组 296 名，对照组 295 名。足月时，干预组的 GWG 从孕前平均为 14.4kg，对照组为 15.8kg（平均差异 1.3kg；95%置信区间，95%CI 0.3-2.3kg；P=0.009）。两组妊娠并发症或剖宫产率无显著差异。干预组对足月婴儿的平均出生体重或巨大儿比例没有影响。
尽管 GWG 略有但显著降低，但挪威 Fit for Delivery 孕期生活方式干预对产科和新生儿结局没有可衡量的影响。
