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产生针对促甲状腺激素反应性抗体的抗独特型抗体的细胞的检测。

Detection of cells producing anti-idiotypic antibody to thyroid stimulating hormone-reactive antibodies.

作者信息

Szabo J, Kruger S R, Beall G N

机构信息

Department of Medicine, Harbor-UCLA Medical Center, Torrance.

出版信息

Immunol Invest. 1989 Aug;18(7):879-84. doi: 10.3109/08820138909050766.

DOI:10.3109/08820138909050766
PMID:2676856
Abstract

BALB/c mice were immunized either with bovine (b) or human (h) thyroid stimulating hormone (TSH) or with one of several mouse monoclonal anti-hTSH antibodies. The binding of biotinylated mouse monoclonal anti-hTSH to sections of spleen, kidney, liver and lung was assessed with fluorescein isothiocyanate labelled avidin. Clusters of cells in the spleens of mice immunized with bTSH bound the labelled monoclonal anti-TSH. We suggest that these cells synthesized auto-anti-idiotypic antibodies to anti-TSH.

摘要

用牛（b）或人（h）促甲状腺激素（TSH）或几种小鼠抗人促甲状腺激素单克隆抗体之一对BALB/c小鼠进行免疫。用异硫氰酸荧光素标记的抗生物素蛋白评估生物素化的小鼠抗人促甲状腺激素单克隆抗体与脾脏、肾脏、肝脏和肺组织切片的结合。用牛促甲状腺激素免疫的小鼠脾脏中的细胞簇与标记的抗促甲状腺激素单克隆抗体结合。我们认为这些细胞合成了针对抗促甲状腺激素的自身抗独特型抗体。

相似文献

1
Detection of cells producing anti-idiotypic antibody to thyroid stimulating hormone-reactive antibodies.产生针对促甲状腺激素反应性抗体的抗独特型抗体的细胞的检测。
Immunol Invest. 1989 Aug;18(7):879-84. doi: 10.3109/08820138909050766.
2
Studies on auto-anti-idiotypic thyroid-stimulating antibodies.自身抗独特型促甲状腺抗体的研究。
Int Arch Allergy Appl Immunol. 1986;81(4):351-6. doi: 10.1159/000234162.
3
Rabbits immunized with thyroid-stimulating hormone produce autoantiidiotypic thyroid-stimulating antibodies.用促甲状腺激素免疫的兔子会产生自身抗独特型促甲状腺抗体。
J Clin Invest. 1985 May;75(5):1435-40. doi: 10.1172/JCI111845.
4
Monoclonal antibodies to the thyrotropin receptor raised by an autoantiidiotypic protocol and their relationship to monoclonal autoantibodies from Graves' patients.通过自身抗独特型方案产生的促甲状腺激素受体单克隆抗体及其与格雷夫斯病患者单克隆自身抗体的关系。
Endocrinology. 1988 Jun;122(6):2840-50. doi: 10.1210/endo-122-6-2840.
5
Evidence against the importance in the disease process of antibodies to bovine thyroid-stimulating hormone found in some patients with Graves' disease.在一些格雷夫斯病患者体内发现的抗牛促甲状腺激素抗体在疾病过程中的重要性缺乏证据。
J Clin Endocrinol Metab. 1989 Jan;68(1):107-13. doi: 10.1210/jcem-68-1-107.
6
Use of anti-idiotypic antibodies as probes for the interaction of TSH subunits with its receptor.
J Cell Biochem. 1987 Jul;34(3):151-62. doi: 10.1002/jcb.240340302.
7
Anti-TSH antibody with high specificity to human TSH in sera from a patient with Graves' disease: its isolation from, and interaction with, TSH receptor antibodies.来自一名格雷夫斯病患者血清中对人促甲状腺激素具有高特异性的抗促甲状腺激素抗体：其从促甲状腺激素受体抗体中的分离及其与促甲状腺激素受体抗体的相互作用。
Clin Endocrinol (Oxf). 1987 Mar;26(3):311-20. doi: 10.1111/j.1365-2265.1987.tb00788.x.
8
Monoclonal antiidiotypic antibodies interact with the 93 kilodalton thyrotropin receptor and exhibit heterogeneous biological activities.
Endocrinology. 1991 Mar;128(3):1555-62. doi: 10.1210/endo-128-3-1555.
9
Balb/C mice immunized with either xenogeneic or syngeneic TSH produce immunoglobulins with anti-TSH and thyroid-stimulating activities.
Acta Endocrinol (Copenh). 1991 Nov;125(5):532-7. doi: 10.1530/acta.0.1250532.
10
Coexistence of autoantibody to human thyrotropin (TSH) and autoanti-idiotypic antibody to antihuman TSH antibody in a case with simple goiter.
J Clin Endocrinol Metab. 1990 Nov;71(5):1163-7. doi: 10.1210/jcem-71-5-1163.

引用本文的文献

1
Anti-idiotypes used in immunohistochemistry.免疫组织化学中使用的抗独特型抗体。
Histochem J. 1990 Oct;22(10):519-25. doi: 10.1007/BF01005973.