产生针对促甲状腺激素反应性抗体的抗独特型抗体的细胞的检测。

Detection of cells producing anti-idiotypic antibody to thyroid stimulating hormone-reactive antibodies.

作者信息

Szabo J, Kruger S R, Beall G N

机构信息

Department of Medicine, Harbor-UCLA Medical Center, Torrance.

出版信息

Immunol Invest. 1989 Aug;18(7):879-84. doi: 10.3109/08820138909050766.

DOI:10.3109/08820138909050766

Abstract

BALB/c mice were immunized either with bovine (b) or human (h) thyroid stimulating hormone (TSH) or with one of several mouse monoclonal anti-hTSH antibodies. The binding of biotinylated mouse monoclonal anti-hTSH to sections of spleen, kidney, liver and lung was assessed with fluorescein isothiocyanate labelled avidin. Clusters of cells in the spleens of mice immunized with bTSH bound the labelled monoclonal anti-TSH. We suggest that these cells synthesized auto-anti-idiotypic antibodies to anti-TSH.

摘要

用牛（b）或人（h）促甲状腺激素（TSH）或几种小鼠抗人促甲状腺激素单克隆抗体之一对BALB/c小鼠进行免疫。用异硫氰酸荧光素标记的抗生物素蛋白评估生物素化的小鼠抗人促甲状腺激素单克隆抗体与脾脏、肾脏、肝脏和肺组织切片的结合。用牛促甲状腺激素免疫的小鼠脾脏中的细胞簇与标记的抗促甲状腺激素单克隆抗体结合。我们认为这些细胞合成了针对抗促甲状腺激素的自身抗独特型抗体。

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Detection of cells producing anti-idiotypic antibody to thyroid stimulating hormone-reactive antibodies.产生针对促甲状腺激素反应性抗体的抗独特型抗体的细胞的检测。

Immunol Invest. 1989 Aug;18(7):879-84. doi: 10.3109/08820138909050766.

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