• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用促甲状腺激素免疫的兔子会产生自身抗独特型促甲状腺抗体。

Rabbits immunized with thyroid-stimulating hormone produce autoantiidiotypic thyroid-stimulating antibodies.

作者信息

Beall G N, Rapoport B, Chopra I J, Kruger S R

出版信息

J Clin Invest. 1985 May;75(5):1435-40. doi: 10.1172/JCI111845.

DOI:10.1172/JCI111845
PMID:2860123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC425480/
Abstract

We immunized rabbits with thyroid-stimulating hormone (TSH) to investigate the hypothesis that such immunization could result in production of thyroid-stimulating autoantiidiotypic antibodies to anti-TSH. Thyroid-stimulating immunoglobulin (TSI) appeared in the serum of several rabbits after immunization. At 160 d, TSI equivalent to 6-18 microU TSH/1.5 mg IgG was present in two of six human (h)TSH-, two of six hTSH beta chain-, and two of the four surviving bovine (b)TSH-immunized animals. Control (human serum albumin-immunized rabbits) serum TSI was 4.3 +/- 0.4 (mean +/- SD) at this time. Antiidiotypic antibodies that could bind to monoclonal anti-hTSH were found in the sera of the bTSH-immunized rabbits. The peak TSI activity occurred 3 mo after a TSH booster immunization and declined gradually during subsequent weeks. Evidence that antiidiotypic antibodies to anti-TSH can cause thyroid stimulation strengthens the notion that such antibodies may be the cause of Graves' hyperthyroidism.

摘要

我们用促甲状腺激素（TSH）免疫兔子，以研究这样的免疫是否会导致产生针对抗TSH的促甲状腺自身抗独特型抗体这一假说。免疫后，几只兔子的血清中出现了促甲状腺免疫球蛋白（TSI）。在160天时，6只用人促甲状腺激素（hTSH）免疫的兔子中有2只、6只用人促甲状腺激素β链免疫的兔子中有2只，以及4只存活的用牛促甲状腺激素（bTSH）免疫的动物中有2只，其TSI相当于6 - 18微单位TSH/1.5毫克IgG。此时，对照（用人血清白蛋白免疫的兔子）血清TSI为4.3±0.4（平均值±标准差）。在用bTSH免疫的兔子血清中发现了能与单克隆抗hTSH结合的抗独特型抗体。TSI活性峰值在TSH加强免疫后3个月出现，并在随后几周逐渐下降。抗TSH的抗独特型抗体可引起甲状腺刺激的证据强化了这样一种观念，即此类抗体可能是格雷夫斯甲亢的病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/6c2baf852b85/jcinvest00140-0055-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/3b212a99a351/jcinvest00140-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/c16a97d35641/jcinvest00140-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/932fbfff72f4/jcinvest00140-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/6c2baf852b85/jcinvest00140-0055-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/3b212a99a351/jcinvest00140-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/c16a97d35641/jcinvest00140-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/932fbfff72f4/jcinvest00140-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7983/425480/6c2baf852b85/jcinvest00140-0055-d.jpg

相似文献

1
Rabbits immunized with thyroid-stimulating hormone produce autoantiidiotypic thyroid-stimulating antibodies.用促甲状腺激素免疫的兔子会产生自身抗独特型促甲状腺抗体。
J Clin Invest. 1985 May;75(5):1435-40. doi: 10.1172/JCI111845.
2
Studies on auto-anti-idiotypic thyroid-stimulating antibodies.自身抗独特型促甲状腺抗体的研究。
Int Arch Allergy Appl Immunol. 1986;81(4):351-6. doi: 10.1159/000234162.
3
Evidence against the importance in the disease process of antibodies to bovine thyroid-stimulating hormone found in some patients with Graves' disease.在一些格雷夫斯病患者体内发现的抗牛促甲状腺激素抗体在疾病过程中的重要性缺乏证据。
J Clin Endocrinol Metab. 1989 Jan;68(1):107-13. doi: 10.1210/jcem-68-1-107.
4
Monoclonal antibodies to the thyrotropin receptor raised by an autoantiidiotypic protocol and their relationship to monoclonal autoantibodies from Graves' patients.通过自身抗独特型方案产生的促甲状腺激素受体单克隆抗体及其与格雷夫斯病患者单克隆自身抗体的关系。
Endocrinology. 1988 Jun;122(6):2840-50. doi: 10.1210/endo-122-6-2840.
5
Anti-TSH antibody with high specificity to human TSH in sera from a patient with Graves' disease: its isolation from, and interaction with, TSH receptor antibodies.来自一名格雷夫斯病患者血清中对人促甲状腺激素具有高特异性的抗促甲状腺激素抗体：其从促甲状腺激素受体抗体中的分离及其与促甲状腺激素受体抗体的相互作用。
Clin Endocrinol (Oxf). 1987 Mar;26(3):311-20. doi: 10.1111/j.1365-2265.1987.tb00788.x.
6
Immunoglobulins of untreated Graves' patients with or without thyrotropin receptor antibody (determined by porcine thyrocytes) universally elicit potent thyroid hormone-releasing activity in cultured human thyroid follicles.未经治疗的伴有或不伴有促甲状腺素受体抗体（通过猪甲状腺细胞测定）的格雷夫斯病患者的免疫球蛋白，在培养的人甲状腺滤泡中普遍引发强大的甲状腺激素释放活性。
Thyroid. 1999 Oct;9(10):979-88. doi: 10.1089/thy.1999.9.979.
7
The effects on rabbits of immunization with bovine thyroid-stimulating hormone and its subunits.牛促甲状腺激素及其亚基免疫对兔子的影响。
J Clin Invest. 1973 Dec;52(12):2986-92. doi: 10.1172/JCI107496.
8
Detection of cells producing anti-idiotypic antibody to thyroid stimulating hormone-reactive antibodies.产生针对促甲状腺激素反应性抗体的抗独特型抗体的细胞的检测。
Immunol Invest. 1989 Aug;18(7):879-84. doi: 10.3109/08820138909050766.
9
Production, isolation, and characterization of rabbit anti-idiotypic antibodies directed against human antithyrotrophin receptor antibodies.兔抗人抗促甲状腺素受体抗体独特型抗体的制备、分离及特性鉴定
J Clin Invest. 1984 Aug;74(2):488-95. doi: 10.1172/JCI111446.
10
Antithyrotropin antibodies in the sera of Graves' disease patients.格雷夫斯病患者血清中的抗促甲状腺素抗体。
J Clin Endocrinol Metab. 1985 Aug;61(2):217-22. doi: 10.1210/jcem-61-2-217.

引用本文的文献

1
Selective isolation of large segments from individual microbial genomes and environmental DNA samples using transformation-associated recombination cloning in yeast.利用酵母中转化相关重组克隆技术从单个微生物基因组和环境 DNA 样本中选择性分离大片段。
Nat Protoc. 2020 Mar;15(3):734-749. doi: 10.1038/s41596-019-0280-1. Epub 2020 Jan 31.
2
Idiotypes and autoimmunity.独特型与自身免疫
Clin Exp Immunol. 1986 Jul;65(1):1-9.
3
The idiotype-antiidiotype network in human autoimmunity.人类自身免疫中的独特型-抗独特型网络。

本文引用的文献

1
Anti-idiotype as antibody against the formyl peptide chemotaxis receptor of the neutrophil.抗独特型作为针对中性粒细胞甲酰肽趋化受体的抗体。
J Immunol. 1982 Feb;128(2):963-8.
2
Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin.在用胰岛素免疫的小鼠中，胰岛素受体自身抗体作为抗独特型抗体自发产生。
Science. 1982 Apr 30;216(4545):542-5. doi: 10.1126/science.7041258.
3
Specific binding of thyroid-stimulating hormone by human serum globulins.人血清球蛋白对促甲状腺激素的特异性结合。
J Clin Immunol. 1985 Nov;5(6):365-9. doi: 10.1007/BF00915332.
4
Distribution of anti-F(ab')2 antibodies and the 16/6 idiotype in systemic lupus erythematosus (SLE) probands and kindreds.系统性红斑狼疮（SLE）先证者及亲属中抗F(ab')2抗体和16/6独特型的分布情况。
J Clin Immunol. 1989 Nov;9(6):462-8. doi: 10.1007/BF00918015.
5
Improvement of infiltrative ophthalmopathy in parallel with decrease of thyroid-stimulating antibody (TSAb) activity in two patients with hypothyroid Graves' disease.两名甲状腺功能减退型格雷夫斯病患者的浸润性眼病改善与促甲状腺素抗体（TSAb）活性降低同步出现。
J Endocrinol Invest. 1989 Jan;12(1):47-53. doi: 10.1007/BF03349918.
J Endocrinol. 1981 Mar;88(3):339-49. doi: 10.1677/joe.0.0880339.
4
Presence of circulating anti-idiotype-bearing cells after booster immunization with tetanus toxoid (TT) and inhibition of anti-TT antibody synthesis by auto-anti-idiotypic antibody.破伤风类毒素（TT）加强免疫后循环中抗独特型细胞的存在以及自身抗独特型抗体对抗TT抗体合成的抑制作用。
J Immunol. 1983 Apr;130(4):1634-9.
5
Biological activity of anti-thyrotropin anti-idiotypic antibody.抗促甲状腺素抗独特型抗体的生物活性。
Eur J Immunol. 1983 Jan;13(1):57-63. doi: 10.1002/eji.1830130113.
6
Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase.抗阿普洛尔抗独特型抗体与β-肾上腺素能受体结合并调节儿茶酚胺敏感的腺苷酸环化酶。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7385-9. doi: 10.1073/pnas.77.12.7385.
7
Binding of 125I-human TSH by gamma globulins of sera containing thyroid-stimulating immunoglobulin (TSI).含甲状腺刺激免疫球蛋白（TSI）的血清γ球蛋白对125I-人促甲状腺激素的结合作用。
Life Sci. 1983;32(1-2):77-83. doi: 10.1016/0024-3205(83)90175-3.
8
Clinical experience with a human thyroid cell bioassay for thyroid-stimulating immunoglobulin.用于检测促甲状腺免疫球蛋白的人甲状腺细胞生物测定法的临床经验。
J Clin Endocrinol Metab. 1984 Feb;58(2):332-8. doi: 10.1210/jcem-58-2-332.
9
Pathogenesis of hyperthyroidism.甲状腺功能亢进症的发病机制。
Annu Rev Med. 1983;34:267-81. doi: 10.1146/annurev.me.34.020183.001411.
10
Thyroid-stimulating immunoglobulins.促甲状腺素受体抗体
Horm Res. 1982;16(5):317-28. doi: 10.1159/000179520.