Okely Judith A, Cooper Cyrus, Gale Catharine R
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Ann Behav Med. 2016 Jun;50(3):419-26. doi: 10.1007/s12160-015-9764-6.
A number of studies provide evidence for an association between psychosocial factors and risk of incident arthritis. Current evidence is largely limited to the examination of negative factors such as perceived stress, but positive factors such as subjective wellbeing may also play a role.
The purpose of the current study was to investigate whether people with higher subjective wellbeing have a lower risk of developing arthritis.
We used Cox proportional hazards regression to examine the prospective relationship between wellbeing (measured using the CASP-12) and incidence of arthritis over a 9-year period. The sample consisted of 13,594 participants aged ≥50 years from the Survey of Health, Ageing and Retirement in Europe.
There was a significant association between greater wellbeing and reduced incident arthritis that was stronger at younger ages. In sex-adjusted analyses, for a standard deviation increase in CASP-12 score, the hazard ratios (95 % confidence intervals) for incident arthritis in people aged <65 and ≥65 years were 0.73 (0.69-0.77) and 0.80 (0.77-0.85), respectively. After further adjustment for other established risk factors, these associations were attenuated but remained significant in both age groups: the fully adjusted hazard ratios were 0.82 (0.77-0.87) and 0.88 (0.82-0.95), respectively.
These results provide evidence for an association between greater wellbeing and reduced risk of incident arthritis and, more generally, support the theory that psychosocial factors are implicated in the aetiology of this disease. Future research needs to delineate the mechanisms underlying the association between wellbeing and arthritis risk.
多项研究为心理社会因素与关节炎发病风险之间的关联提供了证据。目前的证据在很大程度上局限于对诸如感知压力等负面因素的研究，但诸如主观幸福感等积极因素可能也起作用。
本研究旨在调查主观幸福感较高的人患关节炎的风险是否较低。
我们使用Cox比例风险回归来研究幸福感（使用CASP-12量表测量）与9年期间关节炎发病率之间的前瞻性关系。样本包括来自欧洲健康、老龄化和退休调查的13594名年龄≥50岁的参与者。
幸福感增强与关节炎发病率降低之间存在显著关联，且在较年轻年龄段这种关联更强。在按性别调整的分析中，CASP-12得分每增加一个标准差，年龄<65岁和≥65岁人群患关节炎的风险比（95%置信区间）分别为0.73（0.69 - 0.77）和0.80（0.77 - 0.85）。在进一步调整其他既定风险因素后，这些关联有所减弱，但在两个年龄组中仍具有显著性：完全调整后的风险比分别为0.82（0.77 - 0.87）和0.88（0.82 - 0.95）。
这些结果为幸福感增强与关节炎发病风险降低之间的关联提供了证据，更广泛地说，支持了心理社会因素与该疾病病因有关的理论。未来的研究需要阐明幸福感与关节炎风险之间关联的潜在机制。
