Engst R, Huber J
Dermatologische Klinik und Poliklinik, Technischen Universität München.
Hautarzt. 1989 Aug;40(8):486-9.
Controlled double-blind studies have demonstrated the efficacy of 14 mg/kg per day cyclosporin A (CsA) in patients with severe psoriasis. Recently a placebo-controlled double-blind randomized study confirmed that CsA therapy (mean dose 5.5 mg/kg/day improves psoriasis significantly. We have carried out a placebo-controlled, double-blind, randomized trial involving 12 patients suffering from severe psoriasis resistant to local therapy. Within 4 weeks, 5 mg/kg per day CsA resulted in 6 patients in a mean reduction of 72.5% of the PASI score, which differed significantly from the mean reduction of 18.1% in 6 patients receiving placebo. The most important side-effect was reversible hypertension in 1 patient. The preliminary results of a dose-finding study that started recently indicate that 1-3 mg/kg per day CsA results in a significant improvement in the patient's condition.
对照双盲研究已证明，每天14毫克/千克的环孢素A（CsA）对重度银屑病患者有效。最近一项安慰剂对照双盲随机研究证实，CsA疗法（平均剂量5.5毫克/千克/天）能显著改善银屑病。我们进行了一项安慰剂对照、双盲、随机试验，涉及12名对局部治疗耐药的重度银屑病患者。在4周内，每天5毫克/千克的CsA使6名患者的银屑病面积和严重程度指数（PASI）评分平均降低了72.5%，这与6名接受安慰剂治疗患者的平均降低18.1%有显著差异。最重要的副作用是1名患者出现可逆性高血压。最近开始的一项剂量探索研究的初步结果表明，每天1 - 3毫克/千克的CsA能使患者病情显著改善。
