Bonifati C, Clerico R, Potenza C M, Carlesimo M
Department of Dermatology, University of Rome, Italy.
Acta Derm Venereol Suppl (Stockh). 1989;146:151-4.
Cyclosporin A (CYA) has recently attracted the attention of the dermatologists with regard to its use in the treatment of severe psoriasis. We report four cases of psoriasis resistant to conventional therapy. Three patients were affected by chronic plaque psoriasis and one by erythrodermic psoriasis. The initial dosage of CYA was 5 mg/kg/day per os, and was gradually reduced according to the course of the disease. The drug was administered for a period of 6 weeks. All patients showed a significant improvement of the clinical picture. No remarkable clinical side effects were observed. During the trial we took skin biopsies on which we conducted histological and immunohistochemical studies. The efficacy of CYA in the treatment of psoriasis demonstrates the important role of the cell mediated immunity in the pathogenesis of psoriasis.
环孢素A（CYA）最近在治疗重度银屑病方面引起了皮肤科医生的关注。我们报告了4例对传统疗法耐药的银屑病病例。3例患者患有慢性斑块状银屑病，1例患有红皮病型银屑病。CYA的初始剂量为口服5mg/kg/天，并根据病程逐渐减量。该药物服用了6周。所有患者的临床表现均有显著改善。未观察到明显的临床副作用。在试验期间，我们取了皮肤活检样本并进行了组织学和免疫组化研究。CYA治疗银屑病的疗效证明了细胞介导免疫在银屑病发病机制中的重要作用。
