两种不同生长激素剂量对最终身高和骨骼形态的影响。

The effect of two different GH dosages on final height and bone geometry.

作者信息

Lupi Fiorenzo, Bozzola Mauro, Longhi Silvia, Farello Giovanni, Radetti Giorgio

机构信息

Department of Paediatrics, Regional Hospital, via Lorenz Boehler 5, Bolzano, 39100, Italy.

Internal Medicine and Therapeutics Department, Pediatrics and Adolescentology Unit, University of Pavia, Fondazione IRCCS San Matteo, Viale Golgi 19, Pavia, 27100, Italy.

出版信息

Ital J Pediatr. 2016 Jan 15;42:5. doi: 10.1186/s13052-016-0212-4.

DOI:10.1186/s13052-016-0212-4

PMID:26769291

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4714449/

Abstract

BACKGROUND

Growth hormone (GH) has a strong positive influence on bone, stimulating both bone elongation and increase in size. The aim of the study was to compare the effect of two different GH dosages on final height and bone geometry in two groups of GH-deficient children.

METHODS

We evaluated 121 children (86 m, 35f). Group 1 (77 patients) treated with GH at a mean dose of 0.16 mg/kg/week and group 2 (44 patients) at 0.3 mg/kg/week. Bone geometry was evaluated at final height from a digitalized X-ray of the left hand considering the following parameters: metacarpal index (MI), cross-sectional area (CSA), cortical area (CA) and medullary area (MA).

RESULTS

At baseline, group 2 was shorter than group 1 (-1.54 vs -1.01 SDS; p < 0.005), while at final height there was no difference. Height gain was significantly greater in group 2 than in group 1 (1.62 vs 1.13 SDS; p < 0.001). Bone geometry: MI was significantly greater in group 2 (0.62 vs 0.55; p < 0.001) as well as CA (46.87 vs 42.69 cm(2); p < 0.005), while MA was significantly lower in group 2 (8.48 vs 11.65 cm(2); p < 0.002).

CONCLUSION

Higher GH doses elicit a significantly greater statural gain and a greater bone cortical area.

摘要

背景

生长激素（GH）对骨骼有强烈的正向影响，可刺激骨骼延长和增粗。本研究的目的是比较两组生长激素缺乏儿童使用两种不同剂量生长激素对最终身高和骨骼几何形态的影响。

方法

我们评估了121名儿童（86名男性，35名女性）。第1组（77例患者）接受平均剂量为0.16mg/kg/周的生长激素治疗，第2组（44例患者）接受0.3mg/kg/周的治疗。在达到最终身高时，通过左手数字化X线片评估骨骼几何形态，考虑以下参数：掌骨指数（MI）、横截面积（CSA）、皮质面积（CA）和髓腔面积（MA）。

结果

基线时，第2组比第1组矮（-1.54 vs -1.01 SDS；p<0.005），而在最终身高时无差异。第2组的身高增长显著大于第1组（1.62 vs 1.13 SDS；p<0.001）。骨骼几何形态：第2组的MI显著更大（0.62 vs 0.55；p<0.001），CA也是如此（46.87 vs 42.69 cm²；p<0.005），而第2组的MA显著更低（8.48 vs 11.65 cm²；p<0.002）。