Nurwidya Fariz, Damayanti Triya, Yunus Faisal
Department of Respiratory Medicine, Persahabatan General Hospital, University of Indonesia Faculty of Medicine, Jakarta, Indonesia.
Tuberc Respir Dis (Seoul). 2016 Jan;79(1):5-13. doi: 10.4046/trd.2016.79.1.5. Epub 2015 Dec 31.
Chronic obstructive pulmonary disease (COPD) is a chronic and progressive inflammatory disease of the airways and lungs that results in limitations of continuous airflow and is caused by exposure to noxious gasses and particles. A major cause of morbidity and mortality in adults, COPD is a complex disease pathologically mediated by many inflammatory pathways. Macrophages, neutrophils, dendritic cells, and CD8+ T-lymphocytes are the key inflammatory cells involved in COPD. Recently, the non-coding small RNA, micro-RNA, have also been intensively investigated and evidence suggest that it plays a role in the pathogenesis of COPD. Here, we discuss the accumulated evidence that has since revealed the role of each inflammatory cell and their involvement in the immunopathogenesis of COPD. Mechanisms of steroid resistance in COPD will also be briefly discussed.
慢性阻塞性肺疾病（COPD）是一种气道和肺部的慢性进行性炎症性疾病，导致持续气流受限，由接触有害气体和颗粒引起。COPD是成年人发病和死亡的主要原因，是一种由多种炎症途径病理介导的复杂疾病。巨噬细胞、中性粒细胞、树突状细胞和CD8 + T淋巴细胞是参与COPD的关键炎症细胞。最近，非编码小RNA，即微小RNA，也受到了深入研究，有证据表明它在COPD的发病机制中起作用。在此，我们讨论积累的证据，这些证据揭示了每种炎症细胞的作用及其在COPD免疫发病机制中的参与情况。还将简要讨论COPD中类固醇抵抗的机制。
