转化生长因子-β1基因多态性与肝细胞癌风险的关联：一项荟萃分析。
Association between TGF-β1 polymorphisms and hepatocellular carcinoma risk: a meta-analysis.
作者信息
Guo Ying, Zang Chunbao, Li Yajun, Yuan Li, Liu Qingjun, Zhang Lingyan, Li Shaolin
机构信息
1 Department of Radiology, College of Basic Medicine, Chongqing Medical University , Chongqing, People's Republic of China .
出版信息
Genet Test Mol Biomarkers. 2013 Nov;17(11):814-20. doi: 10.1089/gtmb.2013.0268. Epub 2013 Sep 9.
Abstract
BACKGROUND
Associations between transforming growth factor (TGF)-β1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations.
METHODS
We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.
RESULTS
A total of 14 studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was significantly associated with HCC risk (OR=1.74, 95% CI: 1.22-2.47, p=0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR=1.40, 95% CI: 1.15-1.70, p=0.0007). Furthermore, significant associations between these polymorphisms and HCC risk were found in Asians and population-based studies.
CONCLUSIONS
Our meta-analysis suggested that the TGF-β1 +869C/T and -509C/T polymorphisms may be risk factors for developing HCC.
摘要
背景
转化生长因子（TGF）-β1基因多态性与肝细胞癌（HCC）风险之间的关联仍存在争议。因此，我们进行了这项荟萃分析以研究这些关联。
方法
我们检索了截至2013年3月之前发表在PubMed、EMBASE、中国知网（CNKI）和万方数据库中的研究。采用比值比（OR）及95%置信区间（CI）计算关联强度。
结果
本荟萃分析共纳入14项研究。TGF-β1 +869C/T基因多态性与HCC风险显著相关（OR=1.74，95%CI：1.22-2.47，P=0.002）。此外，还观察到-509C/T基因多态性与HCC风险之间存在显著关联（OR=1.40，95%CI：1.15-1.70，P=0.0007）。此外，在亚洲人群和基于人群的研究中发现这些多态性与HCC风险之间存在显著关联。
结论
我们的荟萃分析表明，TGF-β1 +869C/T和-509C/T基因多态性可能是HCC发生的危险因素。
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2
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3
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4
Polymorphisms in the potential functional regions of the TGF-β 1 and TGF-β receptor genes and disease susceptibility in HBV-related hepatocellular carcinoma patients.潜在功能区域的 TGF-β 1 和 TGF-β 受体基因多态性与 HBV 相关肝细胞癌患者的疾病易感性。
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5
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6
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7
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8
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Oncogene. 2009 Nov 12;28(45):4022-33. doi: 10.1038/onc.2009.253. Epub 2009 Aug 31.
9
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J Gastroenterol Hepatol. 2009 Mar;24(3):346-53. doi: 10.1111/j.1440-1746.2009.05784.x. Epub 2009 Feb 12.
10
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